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STAT Transcription Factors
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
STAT Transcription Factors
Tree Number(s)
D12.644.360.024.342
D12.776.157.057.186
D12.776.476.024.430
D12.776.930.840
Unique ID
D050791
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D050791
Annotation
general; prefer specifics
Scope Note
A family of transcription factors containing
SH2 DOMAINS
that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of
CELL SURFACE RECEPTORS
and are activated via
PHOSPHORYLATION
. Once activated they dimerize and translocate into the
CELL NUCLEUS
where they influence
GENE
expression. They play a role in regulating
CELL GROWTH PROCESSES
and CELL DIFFERENTIATION. STAT transcription factors are inhibited by
SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS
and
PROTEIN INHIBITORS OF ACTIVATED STAT
.
Entry Term(s)
STAT (Signal Transducers and Activators of Transcription) Proteins
Public MeSH Note
2006
History Note
2006
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2016/02/18
Allowable Qualifiers
administration & dosage (AD)
adverse effects (AE)
agonists (AG)
analysis (AN)
antagonists & inhibitors (AI)
biosynthesis (BI)
blood (BL)
cerebrospinal fluid (CF)
chemical synthesis (CS)
chemistry (CH)
classification (CL)
deficiency (DF)
drug effects (DE)
economics (EC)
genetics (GE)
history (HI)
immunology (IM)
isolation & purification (IP)
metabolism (ME)
pharmacokinetics (PK)
pharmacology (PD)
physiology (PH)
poisoning (PO)
radiation effects (RE)
standards (ST)
supply & distribution (SD)
therapeutic use (TU)
toxicity (TO)
ultrastructure (UL)
urine (UR)
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
14-3-3 Proteins [D12.644.360.024.050]
A Kinase Anchor Proteins [D12.644.360.024.065]
Angiomotins [D12.644.360.024.082]
Arrestins [D12.644.360.024.098]
CARD Signaling Adaptor Proteins [D12.644.360.024.131]
Caveolin 1 [D12.644.360.024.264]
Caveolin 2 [D12.644.360.024.272]
Cortactin [D12.644.360.024.280]
Crk-Associated Substrate Protein [D12.644.360.024.282]
Death Domain Receptor Signaling Adaptor Proteins [D12.644.360.024.285]
Discs Large Homolog 1 Protein [D12.644.360.024.287]
Dishevelled Proteins [D12.644.360.024.288]
GRB2 Adaptor Protein [D12.644.360.024.290]
GRB7 Adaptor Protein [D12.644.360.024.299]
GRB10 Adaptor Protein [D12.644.360.024.300]
Insulin Receptor Substrate Proteins [D12.644.360.024.301]
Interferon Regulatory Factors [D12.644.360.024.302]
Interferon-Stimulated Gene Factor 3 [D12.644.360.024.303]
Kelch-Like ECH-Associated Protein 1 [D12.644.360.024.306]
Mediator Complex [D12.644.360.024.309]
mTOR Associated Protein, LST8 Homolog [D12.644.360.024.310]
Myeloid Differentiation Factor 88 [D12.644.360.024.311]
Nod Signaling Adaptor Proteins [D12.644.360.024.313]
Nuclear Receptor Coactivators [D12.644.360.024.314]
Nuclear Receptor Interacting Protein 1 [D12.644.360.024.315]
Paxillin [D12.644.360.024.316]
PII Nitrogen Regulatory Proteins [D12.644.360.024.318]
Protein Inhibitors of Activated STAT [D12.644.360.024.319]
Proto-Oncogene Proteins c-crk [D12.644.360.024.320]
Proto-Oncogene Proteins c-vav [D12.644.360.024.321]
Rabphilin-3A [D12.644.360.024.322]
Rapamycin-Insensitive Companion of mTOR Protein [D12.644.360.024.323]
Regulatory-Associated Protein of mTOR [D12.644.360.024.324]
Retinoblastoma Binding Proteins [D12.644.360.024.328]
Sequestosome-1 Protein [D12.644.360.024.329]
Shc Signaling Adaptor Proteins [D12.644.360.024.330]
Signaling Lymphocytic Activation Molecule Associated Protein [D12.644.360.024.332]
Smad Proteins [D12.644.360.024.334]
STAT Transcription Factors [D12.644.360.024.342]
STAT1 Transcription Factor [D12.644.360.024.342.100]
STAT2 Transcription Factor [D12.644.360.024.342.200]
STAT3 Transcription Factor [D12.644.360.024.342.300]
STAT4 Transcription Factor [D12.644.360.024.342.400]
STAT5 Transcription Factor [D12.644.360.024.342.500]
STAT6 Transcription Factor [D12.644.360.024.342.600]
Suppressor of Cytokine Signaling Proteins [D12.644.360.024.374]
Syntenins [D12.644.360.024.437]
Transcriptional Coactivator with PDZ-Binding Motif Proteins [D12.644.360.024.469]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.644.360.024.500]
YAP-Signaling Proteins [D12.644.360.024.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
5-Lipoxygenase-Activating Proteins [D12.776.157.057.001]
14-3-3 Proteins [D12.776.157.057.002]
A Kinase Anchor Proteins [D12.776.157.057.003]
Arrestins [D12.776.157.057.005]
CARD Signaling Adaptor Proteins [D12.776.157.057.006]
Caveolin 1 [D12.776.157.057.010]
Caveolin 2 [D12.776.157.057.012]
Cortactin [D12.776.157.057.014]
Crk-Associated Substrate Protein [D12.776.157.057.016]
Death Domain Receptor Signaling Adaptor Proteins [D12.776.157.057.018]
Discs Large Homolog 1 Protein [D12.776.157.057.023]
Dishevelled Proteins [D12.776.157.057.028]
GRB10 Adaptor Protein [D12.776.157.057.039]
GRB2 Adaptor Protein [D12.776.157.057.041]
GRB7 Adaptor Protein [D12.776.157.057.043]
Insulin Receptor Substrate Proteins [D12.776.157.057.045]
Interferon Regulatory Factors [D12.776.157.057.050]
Interferon-Stimulated Gene Factor 3 [D12.776.157.057.061]
Kelch-Like ECH-Associated Protein 1 [D12.776.157.057.067]
Mediator Complex [D12.776.157.057.072]
mTOR Associated Protein, LST8 Homolog [D12.776.157.057.073]
Myeloid Differentiation Factor 88 [D12.776.157.057.074]
Nod Signaling Adaptor Proteins [D12.776.157.057.078]
Nuclear Receptor Coactivators [D12.776.157.057.080]
Nuclear Receptor Interacting Protein 1 [D12.776.157.057.086]
Paxillin [D12.776.157.057.092]
PII Nitrogen Regulatory Proteins [D12.776.157.057.110]
Protein Inhibitors of Activated STAT [D12.776.157.057.124]
Proto-Oncogene Proteins c-crk [D12.776.157.057.139]
Proto-Oncogene Proteins c-vav [D12.776.157.057.144]
Rabphilin-3A [D12.776.157.057.150]
Rapamycin-Insensitive Companion of mTOR Protein [D12.776.157.057.155]
Regulatory-Associated Protein of mTOR [D12.776.157.057.157]
Retinoblastoma Binding Proteins [D12.776.157.057.158]
Sequestosome-1 Protein [D12.776.157.057.160]
Shc Signaling Adaptor Proteins [D12.776.157.057.162]
Signaling Lymphocytic Activation Molecule Associated Protein [D12.776.157.057.166]
Smad Proteins [D12.776.157.057.170]
STAT Transcription Factors [D12.776.157.057.186]
STAT1 Transcription Factor [D12.776.157.057.186.100]
STAT2 Transcription Factor [D12.776.157.057.186.200]
STAT3 Transcription Factor [D12.776.157.057.186.300]
STAT4 Transcription Factor [D12.776.157.057.186.400]
STAT5 Transcription Factor [D12.776.157.057.186.500]
STAT6 Transcription Factor [D12.776.157.057.186.600]
Suppressor of Cytokine Signaling Proteins [D12.776.157.057.249]
Syntenins [D12.776.157.057.374]
Transcriptional Coactivator with PDZ-Binding Motif Proteins [D12.776.157.057.437]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.776.157.057.500]
YAP-Signaling Proteins [D12.776.157.057.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
5-Lipoxygenase-Activating Proteins [D12.776.476.024.034]
14-3-3 Proteins [D12.776.476.024.050]
A Kinase Anchor Proteins [D12.776.476.024.069]
Angiomotins [D12.776.476.024.087]
Arrestins [D12.776.476.024.104]
CARD Signaling Adaptor Proteins [D12.776.476.024.139]
Caveolin 1 [D12.776.476.024.280]
Caveolin 2 [D12.776.476.024.295]
Cortactin [D12.776.476.024.311]
Crk-Associated Substrate Protein [D12.776.476.024.316]
Death Domain Receptor Signaling Adaptor Proteins [D12.776.476.024.320]
Discs Large Homolog 1 Protein [D12.776.476.024.325]
Dishevelled Proteins [D12.776.476.024.330]
GRB2 Adaptor Protein [D12.776.476.024.377]
GRB7 Adaptor Protein [D12.776.476.024.379]
GRB10 Adaptor Protein [D12.776.476.024.380]
Homer Scaffolding Proteins [D12.776.476.024.381]
Insulin Receptor Substrate Proteins [D12.776.476.024.382]
Interferon Regulatory Factors [D12.776.476.024.385]
Interferon-Stimulated Gene Factor 3 [D12.776.476.024.386]
Kelch-Like ECH-Associated Protein 1 [D12.776.476.024.387]
Mediator Complex [D12.776.476.024.388]
mTOR Associated Protein, LST8 Homolog [D12.776.476.024.389]
Myeloid Differentiation Factor 88 [D12.776.476.024.390]
Nod Signaling Adaptor Proteins [D12.776.476.024.391]
Nuclear Receptor Coactivators [D12.776.476.024.394]
Nuclear Receptor Interacting Protein 1 [D12.776.476.024.396]
Paxillin [D12.776.476.024.397]
PII Nitrogen Regulatory Proteins [D12.776.476.024.400]
Protein Inhibitors of Activated STAT [D12.776.476.024.402]
Proto-Oncogene Proteins c-crk [D12.776.476.024.404]
Proto-Oncogene Proteins c-vav [D12.776.476.024.407]
Rabphilin-3A [D12.776.476.024.409]
Rapamycin-Insensitive Companion of mTOR Protein [D12.776.476.024.411]
Receptor Activity-Modifying Proteins [D12.776.476.024.414]
Regulatory-Associated Protein of mTOR [D12.776.476.024.419]
Retinoblastoma Binding Proteins [D12.776.476.024.420]
Sequestosome-1 Protein [D12.776.476.024.422]
Shc Signaling Adaptor Proteins [D12.776.476.024.424]
Signaling Lymphocytic Activation Molecule Associated Protein [D12.776.476.024.426]
Smad Proteins [D12.776.476.024.428]
STAT Transcription Factors [D12.776.476.024.430]
STAT1 Transcription Factor [D12.776.476.024.430.100]
STAT2 Transcription Factor [D12.776.476.024.430.200]
STAT3 Transcription Factor [D12.776.476.024.430.300]
STAT4 Transcription Factor [D12.776.476.024.430.400]
STAT5 Transcription Factor [D12.776.476.024.430.500]
STAT6 Transcription Factor [D12.776.476.024.430.600]
Suppressor of Cytokine Signaling Proteins [D12.776.476.024.437]
Syntenins [D12.776.476.024.468]
Transcriptional Coactivator with PDZ-Binding Motif Proteins [D12.776.476.024.484]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.776.476.024.500]
YAP-Signaling Proteins [D12.776.476.024.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
Adenovirus E1A Proteins [D12.776.930.100]
Adenovirus E1B Proteins [D12.776.930.110]
Antennapedia Homeodomain Protein [D12.776.930.120]
AIRE Protein [D12.776.930.123]
Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
beta Catenin [D12.776.930.130]
BRCA1 Protein [D12.776.930.137]
CDX2 Transcription Factor [D12.776.930.146]
Core Binding Factors [D12.776.930.155]
COUP Transcription Factors [D12.776.930.160]
Cyclic AMP Receptor Protein [D12.776.930.165]
E2F Transcription Factors [D12.776.930.211]
Early Growth Response Transcription Factors [D12.776.930.213]
Elongin [D12.776.930.215]
Erythroid-Specific DNA-Binding Factors [D12.776.930.216]
Fushi Tarazu Transcription Factors [D12.776.930.312]
G-Box Binding Factors [D12.776.930.313]
GATA Transcription Factors [D12.776.930.314]
Goosecoid Protein [D12.776.930.315]
Heat Shock Transcription Factors [D12.776.930.317]
Hepatocyte Nuclear Factors [D12.776.930.318]
Homeobox Protein PITX2 [D12.776.930.320]
Homeobox Protein Nkx-2.2 [D12.776.930.321]
Homeobox Protein Nkx-2.5 [D12.776.930.324]
Host Cell Factor C1 [D12.776.930.325]
I-kappa B Proteins [D12.776.930.326]
Immunoglobulin J Recombination Signal Sequence-Binding Protein [D12.776.930.327]
Inhibitor of Differentiation Proteins [D12.776.930.329]
Interferon Regulatory Factors [D12.776.930.332]
Interferon-Stimulated Gene Factor 3 [D12.776.930.354]
Kruppel-Like Transcription Factors [D12.776.930.375]
Leucine-Responsive Regulatory Protein [D12.776.930.386]
MADS Domain Proteins [D12.776.930.397]
MDS1 and EVI1 Complex Locus Protein [D12.776.930.419]
MSX1 Transcription Factor [D12.776.930.440]
Myeloid Ecotropic Viral Integration Site 1 Protein [D12.776.930.462]
Myeloid-Lymphoid Leukemia Protein [D12.776.930.483]
Nanog Homeobox Protein [D12.776.930.542]
NF-kappa B [D12.776.930.600]
NFATC Transcription Factors [D12.776.930.608]
NFI Transcription Factors [D12.776.930.612]
Nuclear Factor 90 Proteins [D12.776.930.616]
Nuclear Receptor Coactivators [D12.776.930.617]
Nuclear Respiratory Factors [D12.776.930.618]
Onecut Transcription Factors [D12.776.930.640]
Orphan Nuclear Receptors [D12.776.930.645]
Otx Transcription Factors [D12.776.930.650]
p300-CBP Transcription Factors [D12.776.930.680]
Paired Box Transcription Factors [D12.776.930.700]
Peroxisome Proliferator-Activated Receptors [D12.776.930.705]
POU Domain Factors [D12.776.930.710]
Pre-B-Cell Leukemia Transcription Factor 1 [D12.776.930.712]
Promyelocytic Leukemia Protein [D12.776.930.713]
B-Cell Lymphoma 3 Protein [D12.776.930.714]
Proto-Oncogene Proteins c-bcl-6 [D12.776.930.715]
Proto-Oncogene Proteins c-ets [D12.776.930.720]
Proto-Oncogene Proteins c-myb [D12.776.930.725]
Proto-Oncogene Proteins c-rel [D12.776.930.730]
Receptors, Aryl Hydrocarbon [D12.776.930.760]
Receptors, Notch [D12.776.930.770]
Receptors, Retinoic Acid [D12.776.930.775]
Receptors, Steroid [D12.776.930.778]
Repressor Proteins [D12.776.930.780]
Rho Factor [D12.776.930.785]
Sigma Factor [D12.776.930.800]
Smad Proteins [D12.776.930.806]
SMARCB1 Protein [D12.776.930.809]
Snail Family Transcription Factors [D12.776.930.815]
SOX Transcription Factors [D12.776.930.823]
STAT Transcription Factors [D12.776.930.840]
STAT1 Transcription Factor [D12.776.930.840.100]
STAT2 Transcription Factor [D12.776.930.840.200]
STAT3 Transcription Factor [D12.776.930.840.300]
STAT4 Transcription Factor [D12.776.930.840.400]
STAT5 Transcription Factor [D12.776.930.840.500]
STAT6 Transcription Factor [D12.776.930.840.600]
T-Box Domain Proteins [D12.776.930.850]
TCF Transcription Factors [D12.776.930.875]
TEA Domain Transcription Factors [D12.776.930.882]
Thyroid Nuclear Factor 1 [D12.776.930.888]
Trans-Activators [D12.776.930.900]
Transcription Factor AP-2 [D12.776.930.907]
Transcription Factor DP1 [D12.776.930.908]
Transcription Factor MTF-1 [D12.776.930.919]
Transcription Factors, General [D12.776.930.930]
Transcriptional Elongation Factors [D12.776.930.955]
Tristetraprolin [D12.776.930.960]
Tumor Protein p73 [D12.776.930.969]
Winged-Helix Transcription Factors [D12.776.930.977]
Expand All
Collapse All
STAT Transcription Factors
Preferred
Concept UI
M0477894
Scope Note
A family of transcription factors containing
SH2 DOMAINS
that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of
CELL SURFACE RECEPTORS
and are activated via
PHOSPHORYLATION
. Once activated they dimerize and translocate into the
CELL NUCLEUS
where they influence
GENE
expression. They play a role in regulating
CELL GROWTH PROCESSES
and CELL DIFFERENTIATION. STAT transcription factors are inhibited by
SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS
and
PROTEIN INHIBITORS OF ACTIVATED STAT
.
Terms
STAT Transcription Factors
Preferred Term
Term UI
T624412
Date
12/16/2004
LexicalTag
ABX
ThesaurusID
NLM (2006)
STAT (Signal Transducers and Activators of Transcription) Proteins
Term UI
T624410
Date
12/16/2004
LexicalTag
ABX
ThesaurusID
NLM (2006)
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