MeSH Browser

MeSH Heading: BRCA1 Protein
Tree Number(s): D12.776.313.125; D12.776.624.776.100; D12.776.660.100; D12.776.744.100; D12.776.930.137
Unique ID: D019313
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019313
Scope Note: The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
Entry Term(s): BRCA1 Gene Product; Breast Cancer 1 Gene Product; Breast Cancer 1 Protein; Breast Cancer Type 1 Susceptibility Protein; Ring Finger Protein 53
NLM Classification #: WP 870
Previous Indexing: Neoplasm Proteins (1994-1996); Transcription Factors (1994-1996)
See Also: Genes, BRCA1; Hereditary Breast and Ovarian Cancer Syndrome
Public MeSH Note: 97; BCRA1 PROTEIN was indexed under NEOPLASM PROTEINS & TRANSCRIPTION FACTORS 1994-96
Online Note: use BRCA1 PROTEIN (NM) to search BRCA1 PROTEIN 1994-96
History Note: 97; was BRCA1 PROTEIN (NM) 1994-96
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2015/11/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0028758
Scope Note: The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
Terms: BRCA1 Protein Preferred Term
Term UI T057565
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1997); BRCA1 Gene Product
Term UI T057564
Date12/13/1995
LexicalTag NON
ThesaurusID NLM (1997); Breast Cancer 1 Gene Product
Term UI T431453
Date12/20/2000
LexicalTag NON
ThesaurusID NLM (2002); Breast Cancer 1 Protein
Term UI T637886
Date04/26/2005
LexicalTag NON
ThesaurusID NLM (2006); Ring Finger Protein 53
Term UI T000888523
Date10/26/2015
LexicalTag NON
ThesaurusID NLM (2017); Breast Cancer Type 1 Susceptibility Protein
Term UI T000888524
Date10/26/2015
LexicalTag NON
ThesaurusID NLM (2017)

BRCA1 Protein MeSH Descriptor Data 2025