MeSH Browser

MeSH Heading: Silent Information Regulator Proteins, Saccharomyces cerevisiae
Tree Number(s): D12.776.354.750.750; D12.776.660.820
Unique ID: D038281
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D038281
Scope Note: A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.
Entry Version: SILENT INFORMATION REGULAT PROTEINS SACCH CEREV
Entry Term(s): SIR Proteins, S cerevisiae; Silent Information Regulator Proteins, S cerevisiae; Silent Mating Type Information Regulator Protein, S cerevisiae
See Also: Sirtuins
Public MeSH Note: 2003
History Note: 2003
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0415710
Scope Note: A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.
Terms: Silent Information Regulator Proteins, Saccharomyces cerevisiae Preferred Term
Term UI T483540
Date02/26/2002
LexicalTag NON
ThesaurusID NLM (2003); SIR Proteins, S cerevisiae
Term UI T483542
Date02/26/2002
LexicalTag ACX
ThesaurusID NLM (2003); Silent Information Regulator Proteins, S cerevisiae
Term UI T485888
Date03/14/2002
LexicalTag NON
ThesaurusID NLM (2003)

Silent Information Regulator Proteins, Saccharomyces cerevisiae MeSH Descriptor Data 2025