MeSH Browser

MeSH Heading: Karyopherins
Tree Number(s): D12.776.157.530.750.500; D12.776.543.585.750.500; D12.776.660.502
Unique ID: D028884
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D028884
Scope Note: A family of proteins involved in NUCLEOCYTOPLASMIC TRANSPORT. Karyopherins are heteromeric molecules composed of two major types of components, ALPHA KARYOPHERINS and BETA KARYOPHERINS, that function together to transport molecules through the NUCLEAR PORE COMPLEX. Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN bind to karyopherins and participate in the transport process.
Entry Term(s): Exportin; Exportins; Importin; Importins; Karyopherin; Transportin; Transportins
Previous Indexing: Nuclear Proteins (1995-2001); Receptors, Cytoplasmic and Nuclear (1995-2001)
See Also: Active Transport, Cell Nucleus
Public MeSH Note: 2002; IMPORTIN (now KARYOPHERINS) was indexed under NUCLEAR PROTEINS 1995-2001; TRANSPORTIN (now KARYOPHERINS) was indexed under NUCLEAR PROTEINS & RECEPTORS, CYTOPLASMIC AND NUCLEAR 1995-2001
History Note: 2002; use KARYOPHERINS (NM) 1995-2001
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2020/08/13

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0383377
Scope Note: A family of proteins involved in NUCLEOCYTOPLASMIC TRANSPORT. Karyopherins are heteromeric molecules composed of two major types of components, ALPHA KARYOPHERINS and BETA KARYOPHERINS, that function together to transport molecules through the NUCLEAR PORE COMPLEX. Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN bind to karyopherins and participate in the transport process.
Terms: Karyopherins Preferred Term
Term UI T442067
Date04/06/2001
LexicalTag NON
ThesaurusID NLM (2002); Karyopherin
Term UI T000996759
Date11/15/2019
LexicalTag NON
ThesaurusID NLM (2021); Transportin
Term UI T300606
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Transportins
Term UI T442069
Date04/06/2001
LexicalTag NON
ThesaurusID NLM (2002)

Karyopherins MeSH Descriptor Data 2025