MeSH Browser

MeSH Heading: beta Karyopherins
Tree Number(s): D12.776.157.530.750.500.249; D12.776.543.585.750.500.249; D12.776.660.502.500
Unique ID: D028961
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D028961
Scope Note: Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.
Entry Term(s): Importin-beta; Kap95 protein; Karyopherin beta; Karyopherin-beta; Karyopherin-beta Subunit; beta Importins; p92 nuclear protein
Previous Indexing: Nuclear Proteins (1995-2001)
Public MeSH Note: 2002; KARYOPHERIN BETA & IMPORTIN-BETA were indexed under NUCLEAR PROTEINS 1995-2001
History Note: 2002; use BETA KARYOPHERINS (NM) 1995-2001; for IMPORTIN-BETA use KARYOPHERINS (NM) 1995-2001
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0249033
Scope Note: Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.
Terms: beta Karyopherins Preferred Term
Term UI T443990
Date04/24/2001
LexicalTag NON
ThesaurusID NLM (2002); Kap95 protein
Term UI T279033
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); p92 nuclear protein
Term UI T279036
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); Karyopherin beta
Term UI T279038
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Karyopherin-beta
Term UI T443929
Date04/23/2001
LexicalTag NON
ThesaurusID NLM (2002); Karyopherin-beta Subunit
Term UI T443953
Date04/23/2001
LexicalTag NON
ThesaurusID NLM (2002); Importin-beta
Term UI T270475
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); beta Importins
Term UI T443991
Date04/24/2001
LexicalTag NON
ThesaurusID NLM (2002)

beta Karyopherins MeSH Descriptor Data 2025