MeSH Browser

MeSH Heading: Ataxins
Tree Number(s): D12.776.631.069; D12.776.660.075
Unique ID: D000067528
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000067528
Scope Note: A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset.
Entry Term(s): Ataxin; Ataxin Protein; Ataxin Proteins; Spinocerebellar Ataxia Protein; Spinocerebellar Ataxia Proteins
Previous Indexing: Nerve Tissue Proteins (1995-2015); Nuclear Proteins (1995-2015)
See Also: Spinocerebellar Ataxias
Public MeSH Note: 2016
History Note: 2016
Date Established: 2016/01/01
Date of Entry: 2015/07/06
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000599991
Scope Note: A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset.
Terms: Ataxins Preferred Term
Term UI T000871238
Date11/25/2014
LexicalTag NON
ThesaurusID NLM (2016); Ataxin
Term UI T000998068
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Ataxin Protein
Term UI T000998069
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Spinocerebellar Ataxia Protein
Term UI T000998070
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Ataxin Proteins
Term UI T000872147
Date12/15/2014
LexicalTag NON
ThesaurusID NLM (2016); Spinocerebellar Ataxia Proteins
Term UI T000874561
Date02/02/2015
LexicalTag NON
ThesaurusID NLM (2016)

Ataxins MeSH Descriptor Data 2025