MeSH Browser

MeSH Heading: Disks Large Homolog 4 Protein
Tree Number(s): D08.811.913.696.650.450.750; D12.644.360.265; D12.776.476.265; D12.776.543.219; D12.776.631.224
Unique ID: D000076122
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076122
Scope Note: A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.
Entry Term(s): Discs Large Homolog 4 Protein; PSD-95 Protein; PSD95 Protein; Postsynaptic Density Protein 95; SAP-90 Protein; SAP90 Protein; Synapse-Associated Protein 90
Previous Indexing: Intracellular Signaling Peptides and Proteins (2005-2017); Membrane Proteins (2005-2017)
See Also: SAP90-PSD95 Associated Proteins
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000632224
Scope Note: A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.
Terms: Disks Large Homolog 4 Protein Preferred Term
Term UI T000925379
Date05/25/2017
LexicalTag NON
ThesaurusID NLM (2018); Synapse-Associated Protein 90
Term UI T000925372
Date05/25/2017
LexicalTag NON
ThesaurusID NLM (2018); Postsynaptic Density Protein 95
Term UI T000925373
Date05/25/2017
LexicalTag NON
ThesaurusID NLM (2018); SAP90 Protein
Term UI T000925375
Date05/25/2017
LexicalTag ABX
ThesaurusID NLM (2018); SAP-90 Protein
Term UI T000925376
Date05/25/2017
LexicalTag ABX
ThesaurusID NLM (2018); PSD95 Protein
Term UI T000925377
Date05/25/2017
LexicalTag ABX
ThesaurusID NLM (2018); Discs Large Homolog 4 Protein
Term UI T000925380
Date05/25/2017
LexicalTag NON
ThesaurusID NLM (2018); PSD-95 Protein
Term UI T000925378
Date05/25/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Disks Large Homolog 4 Protein MeSH Descriptor Data 2025