MeSH Browser

MeSH Heading: Receptors, N-Methyl-D-Aspartate
Tree Number(s): D12.776.157.530.400.400.500.500; D12.776.543.550.450.500.200.500; D12.776.543.585.400.500.200.500; D12.776.543.750.720.200.450.400.500
Unique ID: D016194
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016194
Scope Note: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
Entry Version: RECEPT NMDA
Entry Term(s): GLUN2A Receptor; Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2A; Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate-Associated Protein 1; N-Methyl D-Aspartate Receptor Subtype 2A; N-Methyl-D-Aspartate Receptor; N-Methyl-D-Aspartate Receptors; N-Methylaspartate Receptors; NMDA Receptor; NMDA Receptor 2A; NMDA Receptor A1; NMDA Receptor-Ionophore Complex; NMDA Receptors; NMDAR1; NMDAR2A Protein; NMDARA1 Protein; Receptor 2A, NMDA; Receptor A1, NMDA; Receptors, N-Methylaspartate; Receptors, NMDA
Registry Numbers: 0; VH92ICR8HX
Related Numbers: VH92ICR8HX
Previous Indexing: Receptors, Cell Surface (1973-1984); Receptors, Neurotransmitter (1985-1990)
Public MeSH Note: 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92
Online Note: use RECEPTORS, N-METHYL-D-ASPARTATE to search RECEPTOR, N-METHYL-D-ASPARTATE & N-METHYL-D-ASPARTATE RECEPTOR 1991-92
History Note: 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92
Date Introduced: 1991/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Channels [D12.776.157.530.400]
        
        Ligand-Gated Ion Channels [D12.776.157.530.400.400]
        
        Receptors, Ionotropic Glutamate [D12.776.157.530.400.400.500]
        
        Receptors, AMPA [D12.776.157.530.400.400.500.100]
        
        Kainic Acid Receptors [D12.776.157.530.400.400.500.200]
        
        Receptors, N-Methyl-D-Aspartate [D12.776.157.530.400.400.500.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Ion Channels [D12.776.543.550.450]
        
        Ligand-Gated Ion Channels [D12.776.543.550.450.500]
        
        Receptors, Ionotropic Glutamate [D12.776.543.550.450.500.200]
        
        Receptors, AMPA [D12.776.543.550.450.500.200.100]
        
        Kainic Acid Receptors [D12.776.543.550.450.500.200.200]
        
        Receptors, N-Methyl-D-Aspartate [D12.776.543.550.450.500.200.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Channels [D12.776.543.585.400]
        
        Ligand-Gated Ion Channels [D12.776.543.585.400.500]
        
        Receptors, Ionotropic Glutamate [D12.776.543.585.400.500.200]
        
        Receptors, AMPA [D12.776.543.585.400.500.200.100]
        
        Kainic Acid Receptors [D12.776.543.585.400.500.200.200]
        
        Receptors, N-Methyl-D-Aspartate [D12.776.543.585.400.500.200.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Neurotransmitter [D12.776.543.750.720]
        
        Receptors, Amino Acid [D12.776.543.750.720.200]
        
        Receptors, Glutamate [D12.776.543.750.720.200.450]
        
        Receptors, Ionotropic Glutamate [D12.776.543.750.720.200.450.400]
        
        Receptors, AMPA [D12.776.543.750.720.200.450.400.100]
        
        Kainic Acid Receptors [D12.776.543.750.720.200.450.400.200]
        
        Receptors, N-Methyl-D-Aspartate [D12.776.543.750.720.200.450.400.500]

Receptors, N-Methyl-D-Aspartate Preferred

Concept UI: M0024713
Registry Numbers: 0
Related Numbers: VH92ICR8HX
Scope Note: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
Terms: Receptors, N-Methyl-D-Aspartate Preferred Term
Term UI T048134
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); N-Methyl-D-Aspartate Receptor
Term UI T000996330
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021); N-Methyl-D-Aspartate Receptors
Term UI T048133
Date02/20/1990
LexicalTag NON
ThesaurusID NLM (1991); N-Methylaspartate Receptors
Term UI T048135
Date04/17/1992
LexicalTag NON
ThesaurusID NLM (1993); NMDA Receptor
Term UI T000996199
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021); NMDA Receptor-Ionophore Complex
Term UI T048132
Date02/20/1990
LexicalTag NON
ThesaurusID NLM (1991); NMDA Receptors
Term UI T048138
Date02/22/1993
LexicalTag NON
ThesaurusID NLM (1994); Receptors, N-Methylaspartate
Term UI T048136
Date02/20/1990
LexicalTag NON
ThesaurusID NLM (1991); Receptors, NMDA
Term UI T048137
Date02/22/1993
LexicalTag NON
ThesaurusID NLM (1994)

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate-Associated Protein 1 Narrower

Concept UI: M0267020
Registry Numbers: 0
Terms: Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate-Associated Protein 1 Preferred Term
Term UI T001148486
Date05/12/2025
LexicalTag NON
ThesaurusID NLM (2011); NMDAR1
Term UI T297021
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (1996); NMDA Receptor A1
Term UI T001148487
Date05/12/2025
LexicalTag ABX
ThesaurusID NLM (1996); NMDARA1 Protein
Term UI T001148488
Date05/12/2025
LexicalTag ABX
ThesaurusID NLM (1996); Receptor A1, NMDA
Term UI T001148489
Date05/12/2025
LexicalTag ABX
ThesaurusID NLM (1996)

N-Methyl D-Aspartate Receptor Subtype 2A Narrower

Concept UI: M0406701
Registry Numbers: VH92ICR8HX
Terms: N-Methyl D-Aspartate Receptor Subtype 2A Preferred Term
Term UI T001148476
Date05/12/2025
LexicalTag NON
ThesaurusID NLM (2006); GLUN2A Receptor
Term UI T001148477
Date05/12/2025
LexicalTag ABX
ThesaurusID NLM (2012); Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2A
Term UI T001148478
Date05/12/2025
LexicalTag NON
ThesaurusID NLM (2006); NMDA Receptor 2A
Term UI T001148479
Date05/12/2025
LexicalTag ABX
ThesaurusID NLM (2001); NMDAR2A Protein
Term UI T001148480
Date05/12/2025
LexicalTag ABX
ThesaurusID NLM (2001); Receptor 2A, NMDA
Term UI T001148481
Date05/12/2025
LexicalTag ABX
ThesaurusID NLM (2001)

Receptors, N-Methyl-D-Aspartate MeSH Descriptor Data 2026