Ligand-Gated Ion Channels MeSH Descriptor Data 2025

MeSH Heading: Ligand-Gated Ion Channels
Tree Number(s): D12.776.157.530.400.400; D12.776.543.550.450.500; D12.776.543.585.400.500
Unique ID: D058446
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D058446
Scope Note: A subclass of ion channels that open or close in response to the binding of specific LIGANDS.
Entry Term(s): Ligand Gated Ion Channel; Ligand-Gated Channel; Ligand-Gated Channels; Ligand-Gated Ion Channel
Previous Indexing: Ion Channels (1979-2010)
Public MeSH Note: 2011
History Note: 2011
Date Established: 2011/01/01
Date of Entry: 2010/06/25
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Channels [D12.776.157.530.400]
        
        Calcium Channels [D12.776.157.530.400.150]
        
        Channelrhodopsins [D12.776.157.530.400.163]
        
        Chloride Channels [D12.776.157.530.400.175]
        
        Cyclic Nucleotide-Gated Cation Channels [D12.776.157.530.400.337]
        
        Gasdermins [D12.776.157.530.400.353]
        
        Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels [D12.776.157.530.400.368]
        
        Ligand-Gated Ion Channels [D12.776.157.530.400.400]
        
        Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.157.530.400.400.100]
        
        Receptors, Ionotropic Glutamate [D12.776.157.530.400.400.500]
        
        Receptors, Purinergic P2X [D12.776.157.530.400.400.750]
        
        Porins [D12.776.157.530.400.500]
        
        Potassium Channels [D12.776.157.530.400.600]
        
        Sodium Channels [D12.776.157.530.400.875]
        
        Transient Receptor Potential Channels [D12.776.157.530.400.901]
        
        Two-Pore Channels [D12.776.157.530.400.950]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Ion Channels [D12.776.543.550.450]
        
        Calcium Channels [D12.776.543.550.450.150]
        
        Channelrhodopsins [D12.776.543.550.450.163]
        
        Chloride Channels [D12.776.543.550.450.175]
        
        Cyclic Nucleotide-Gated Cation Channels [D12.776.543.550.450.452]
        
        Gasdermins [D12.776.543.550.450.464]
        
        Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels [D12.776.543.550.450.476]
        
        Ligand-Gated Ion Channels [D12.776.543.550.450.500]
        
        Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.550.450.500.100]
        
        Receptors, Ionotropic Glutamate [D12.776.543.550.450.500.200]
        
        Receptors, Purinergic P2X [D12.776.543.550.450.500.600]
        
        Porins [D12.776.543.550.450.730]
        
        Potassium Channels [D12.776.543.550.450.750]
        
        Sodium Channels [D12.776.543.550.450.875]
        
        Two-Pore Channels [D12.776.543.550.450.937]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Channels [D12.776.543.585.400]
        
        Calcium Channels [D12.776.543.585.400.150]
        
        Channelrhodopsins [D12.776.543.585.400.163]
        
        Chloride Channels [D12.776.543.585.400.175]
        
        Cyclic Nucleotide-Gated Cation Channels [D12.776.543.585.400.452]
        
        Gasdermins [D12.776.543.585.400.464]
        
        Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels [D12.776.543.585.400.476]
        
        Ligand-Gated Ion Channels [D12.776.543.585.400.500]
        
        Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.585.400.500.100]
        
        Receptors, Ionotropic Glutamate [D12.776.543.585.400.500.200]
        
        Receptors, Purinergic P2X [D12.776.543.585.400.500.600]
        
        Porins [D12.776.543.585.400.730]
        
        Potassium Channels [D12.776.543.585.400.750]
        
        Sodium Channels [D12.776.543.585.400.875]
        
        Transient Receptor Potential Channels [D12.776.543.585.400.901]
        
        Two-Pore Channels [D12.776.543.585.400.950]

Ligand-Gated Ion Channels Preferred

Concept UI: M0542410
Scope Note: A subclass of ion channels that open or close in response to the binding of specific LIGANDS.
Terms: Ligand-Gated Ion Channels Preferred Term
Term UI T763647
Date01/07/2010
LexicalTag NON
ThesaurusID NLM (2011); Ligand-Gated Channel
Term UI T000998293
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Ligand-Gated Ion Channel
Term UI T000996544
Date11/15/2019
LexicalTag NON
ThesaurusID NLM (2021); Ligand-Gated Channels
Term UI T763874
Date01/11/2010
LexicalTag NON
ThesaurusID NLM (2011); Ligand Gated Ion Channel
Term UI T000998872
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021)

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