Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels MeSH Descriptor Data 2023

MeSH Heading: Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Tree Number(s): D12.776.157.530.400.368; D12.776.543.550.450.476; D12.776.543.585.400.476
Unique ID: D064428
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064428
Scope Note: A subgroup of cyclic nucleotide-regulated ION CHANNELS of the superfamily of pore-loop cation channels that are opened by hyperpolarization rather than depolarization. The ion conducting pore passes SODIUM, CALCIUM, and POTASSIUM cations with a preference for potassium.
Entry Term(s): HCN Pacemaker Channels; HCN1 Channel; HCN2 Channel; HCN2 Potassium Channel; HCN3 Channel; HCN4 Channel; Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2; Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 1; Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 3; Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 4; Hyperpolarization Cyclic-Nucleotide Gated Ion Channels; Hyperpolarization-Activated Cation Channel; I(h) Cation Channels; I(h) Channels; Ih Cation Channels; Potassium-Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2
Registry Number: 0
Previous Indexing: Cyclic Nucleotide-Gated Cation Channels (2001-2013)
Public MeSH Note: 2014; see CYCLIC NUCLEOTIDE-GATED CATION CHANNELS 2009-2013; for HCN2 POTASSIUM CHANNEL see ION CHANNELS 2005-2013 and MUSCLE PROTEINS 1999-2005
History Note: 2014
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2016/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Channels [D12.776.157.530.400]
        
        Calcium Channels [D12.776.157.530.400.150]
        
        Channelrhodopsins [D12.776.157.530.400.163]
        
        Chloride Channels [D12.776.157.530.400.175]
        
        Cyclic Nucleotide-Gated Cation Channels [D12.776.157.530.400.337]
        
        Gasdermins [D12.776.157.530.400.353]
        
        Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels [D12.776.157.530.400.368]
        
        Ligand-Gated Ion Channels [D12.776.157.530.400.400]
        
        Porins [D12.776.157.530.400.500]
        
        Potassium Channels [D12.776.157.530.400.600]
        
        Sodium Channels [D12.776.157.530.400.875]
        
        Transient Receptor Potential Channels [D12.776.157.530.400.901]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Ion Channels [D12.776.543.550.450]
        
        Calcium Channels [D12.776.543.550.450.150]
        
        Channelrhodopsins [D12.776.543.550.450.163]
        
        Chloride Channels [D12.776.543.550.450.175]
        
        Cyclic Nucleotide-Gated Cation Channels [D12.776.543.550.450.452]
        
        Gasdermins [D12.776.543.550.450.464]
        
        Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels [D12.776.543.550.450.476]
        
        Ligand-Gated Ion Channels [D12.776.543.550.450.500]
        
        Porins [D12.776.543.550.450.730]
        
        Potassium Channels [D12.776.543.550.450.750]
        
        Sodium Channels [D12.776.543.550.450.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Channels [D12.776.543.585.400]
        
        Calcium Channels [D12.776.543.585.400.150]
        
        Channelrhodopsins [D12.776.543.585.400.163]
        
        Chloride Channels [D12.776.543.585.400.175]
        
        Cyclic Nucleotide-Gated Cation Channels [D12.776.543.585.400.452]
        
        Gasdermins [D12.776.543.585.400.464]
        
        Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels [D12.776.543.585.400.476]
        
        Ligand-Gated Ion Channels [D12.776.543.585.400.500]
        
        Porins [D12.776.543.585.400.730]
        
        Potassium Channels [D12.776.543.585.400.750]
        
        Sodium Channels [D12.776.543.585.400.875]
        
        Transient Receptor Potential Channels [D12.776.543.585.400.901]

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Preferred

Concept UI: M0507996
Registry Number: 0
Scope Note: A subgroup of cyclic nucleotide-regulated ION CHANNELS of the superfamily of pore-loop cation channels that are opened by hyperpolarization rather than depolarization. The ion conducting pore passes SODIUM, CALCIUM, and POTASSIUM cations with a preference for potassium.
Terms: Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Preferred Term
Term UI T838064
Date03/01/2013
LexicalTag NON
ThesaurusID NLM (2014); Ih Cation Channels
Term UI T838175
Date03/05/2013
LexicalTag NON
ThesaurusID NLM (2014); Hyperpolarization Cyclic-Nucleotide Gated Ion Channels
Term UI T694196
Date03/22/2007
LexicalTag NON
ThesaurusID NLM (2008); I(h) Channels
Term UI T838177
Date03/05/2013
LexicalTag NON
ThesaurusID NLM (2014); Hyperpolarization-Activated Cation Channel
Term UI T838178
Date03/05/2013
LexicalTag NON
ThesaurusID NLM (2014); HCN Pacemaker Channels
Term UI T842968
Date04/23/2013
LexicalTag NON
ThesaurusID NLM (2014); I(h) Cation Channels
Term UI T838176
Date03/05/2013
LexicalTag NON
ThesaurusID NLM (2014)

HCN4 Channel Narrower

HCN3 Channel Narrower

HCN1 Channel Narrower

HCN2 Channel Narrower

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