MeSH Browser

MeSH Heading: Transient Receptor Potential Channels
Tree Number(s): D12.776.157.530.400.901; D12.776.543.585.400.901
Unique ID: D050051
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050051
Annotation: note entry terms: TRP refers to transient receptor potential not TRYPTOPHAN
Scope Note: A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
Entry Version: TRANSIENT RECEPT POTENTIAL CHANNELS
Entry Term(s): TRP Cation Channel; TRP Cation Channels; TRP Membrane Proteins; Transient Receptor Potential Cation Channel; Transient Receptor Potential Cation Channels; Transient Receptor Potential Channel
Previous Indexing: Calcium Channels (1989-2005); Ion Channels (1995-2005)
Public MeSH Note: 2006
History Note: 2006
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Channels [D12.776.157.530.400]
        
        Calcium Channels [D12.776.157.530.400.150]
        
        Channelrhodopsins [D12.776.157.530.400.163]
        
        Chloride Channels [D12.776.157.530.400.175]
        
        Cyclic Nucleotide-Gated Cation Channels [D12.776.157.530.400.337]
        
        Gasdermins [D12.776.157.530.400.353]
        
        Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels [D12.776.157.530.400.368]
        
        Ligand-Gated Ion Channels [D12.776.157.530.400.400]
        
        Porins [D12.776.157.530.400.500]
        
        Potassium Channels [D12.776.157.530.400.600]
        
        Sodium Channels [D12.776.157.530.400.875]
        
        Transient Receptor Potential Channels [D12.776.157.530.400.901]
        
        TRPA1 Cation Channel [D12.776.157.530.400.901.250]
        
        TRPC Cation Channels [D12.776.157.530.400.901.500]
        
        TRPM Cation Channels [D12.776.157.530.400.901.555]
        
        TRPP Cation Channels [D12.776.157.530.400.901.777]
        
        TRPV Cation Channels [D12.776.157.530.400.901.888]
        
        Two-Pore Channels [D12.776.157.530.400.950]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Channels [D12.776.543.585.400]
        
        Calcium Channels [D12.776.543.585.400.150]
        
        Channelrhodopsins [D12.776.543.585.400.163]
        
        Chloride Channels [D12.776.543.585.400.175]
        
        Cyclic Nucleotide-Gated Cation Channels [D12.776.543.585.400.452]
        
        Gasdermins [D12.776.543.585.400.464]
        
        Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels [D12.776.543.585.400.476]
        
        Ligand-Gated Ion Channels [D12.776.543.585.400.500]
        
        Porins [D12.776.543.585.400.730]
        
        Potassium Channels [D12.776.543.585.400.750]
        
        Sodium Channels [D12.776.543.585.400.875]
        
        Transient Receptor Potential Channels [D12.776.543.585.400.901]
        
        TRPA1 Cation Channel [D12.776.543.585.400.901.250]
        
        TRPC Cation Channels [D12.776.543.585.400.901.500]
        
        TRPM Cation Channels [D12.776.543.585.400.901.555]
        
        TRPP Cation Channels [D12.776.543.585.400.901.777]
        
        Two-Pore Channels [D12.776.543.585.400.950]

Transient Receptor Potential Channels Preferred

Concept UI: M0472345
Scope Note: A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
Terms: Transient Receptor Potential Channels Preferred Term
Term UI T608887
Date09/10/2004
LexicalTag NON
ThesaurusID NLM (2006); TRP Cation Channel
Term UI T000996786
Date11/15/2019
LexicalTag NON
ThesaurusID NLM (2021); Transient Receptor Potential Channel
Term UI T000996785
Date11/15/2019
LexicalTag NON
ThesaurusID NLM (2021); TRP Cation Channels
Term UI T608888
Date09/10/2004
LexicalTag ACX
ThesaurusID NLM (2006); TRP Membrane Proteins
Term UI T608889
Date09/10/2004
LexicalTag ACX
ThesaurusID NLM (2006); Transient Receptor Potential Cation Channel
Term UI T000996787
Date11/15/2019
LexicalTag NON
ThesaurusID NLM (2021); Transient Receptor Potential Cation Channels
Term UI T000894415
Date01/29/2016
LexicalTag NON
ThesaurusID NLM (2017)

Transient Receptor Potential Channels MeSH Descriptor Data 2025