MeSH Browser

MeSH Heading: Protoporphyrinogen Oxidase
Tree Number(s): D08.811.682.660.600; D12.776.543.697
Unique ID: D050768
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050768
Scope Note: A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the HEME and CHLOROPHYLL pathways in plants, and is the molecular target of diphenyl ether-type herbicides. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of protoporphyrinogen oxidase.
Entry Term(s): Protoporphyrinogen Dehydrogenase; Protoporphyrinogen IX Oxidase; Protoporphyrinogenase; Protox
Previous Indexing: Oxidoreductases (1993-2003); Oxidoreductases Acting on CH-CH Group Donors (2004-2005); Porphyrins (1975-1976); Protoporphyrins (1975-1982)
Public MeSH Note: 2006; PROTOPORPHYRINOGEN OXIDASE was indexed under OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS 2004-2005, under OXIDOREDUCTASES 1993-2003, under PORPHYRINS 1975-1976, and under PROTOPORPHYRINS 1975-1982
History Note: 2006(1975)
Entry Combination: deficiency:Porphyria, Variegate
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2009/07/15

Entry Combination: deficiency:Porphyria, Variegate
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0078571
Scope Note: A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the HEME and CHLOROPHYLL pathways in plants, and is the molecular target of diphenyl ether-type herbicides. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of protoporphyrinogen oxidase.
Terms: Protoporphyrinogen Oxidase Preferred Term
Term UI T108574
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Protoporphyrinogen Dehydrogenase
Term UI T108571
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Protoporphyrinogen IX Oxidase
Term UI T108570
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Protoporphyrinogenase
Term UI T108572
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Protox
Term UI T623808
Date12/13/2004
LexicalTag NON
ThesaurusID NLM (2006)

Protoporphyrinogen Oxidase MeSH Descriptor Data 2025