MeSH Browser

MeSH Heading: Coproporphyrinogen Oxidase
Tree Number(s): D08.811.682.660.250
Unique ID: D003304
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003304
Scope Note: An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.
Entry Term(s): Coproporphyrinogen III Oxidases; Coproporphyrinogenase
CAS Type 1 Name: Coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
Previous Indexing: Carboxy-Lyases (1972-1974); Coproporphyrins (1975); Oxidoreductases (1975); Porphyrins (1972-1974)
Public MeSH Note: 91; was see under OXIDOREDUCTASES 1976-90
History Note: 91(76); was see under OXIDOREDUCTASES 1976-90
Entry Combination: deficiency:Coproporphyria, Hereditary
Date Established: 1991/01/01
Date of Entry: 1975/07/25
Revision Date: 2008/07/08

Entry Combination: deficiency:Coproporphyria, Hereditary
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Coproporphyrinogen Oxidase MeSH Descriptor Data 2025