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Coproporphyrinogen Oxidase MeSH Descriptor Data 2023


MeSH Heading
Coproporphyrinogen Oxidase
Tree Number(s)
D08.811.682.660.250
Unique ID
D003304
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D003304
Scope Note
An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.
Entry Term(s)
Coproporphyrinogen III Oxidases
Coproporphyrinogenase
Registry Number
EC 1.3.3.3
CAS Type 1 Name
Coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
Previous Indexing
Carboxy-Lyases (1972-1974)
Coproporphyrins (1975)
Oxidoreductases (1975)
Porphyrins (1972-1974)
Public MeSH Note
91; was see under OXIDOREDUCTASES 1976-90
History Note
91(76); was see under OXIDOREDUCTASES 1976-90
Entry Combination
deficiency:Coproporphyria, Hereditary
Date Established
1991/01/01
Date of Entry
1975/07/25
Revision Date
2008/07/08
Coproporphyrinogen Oxidase Preferred
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