MeSH Browser

MeSH Heading: Dihydrouracil Dehydrogenase (NAD+)
Tree Number(s): D08.811.682.660.325
Unique ID: D050744
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050744
Scope Note: An enzyme that catalyzes the oxidation of 5,6-dihydrouracil to URACIL using NAD as a cofactor. This enzyme also plays a role in the catabolism of the antimetabolite 5-FLUOROURACIL.
Entry Term(s): Dihydrothymine Dehydrogenase (NAD); Dihydrouracil Dehydrogenase; Dihydrouracil Dehydrogenase (NAD)
Registry Number: EC 1.3.1.1
Related Numbers: 9026-89-5
Previous Indexing: Oxidoreductases (1983-2003); Oxidoreductases Acting on CH-CH Group Donors (2004-2005)
Public MeSH Note: 2006; DIHYDROURACIL DEHYDROGENASE (NAD+) was indexed under OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS 2004-2005, OXIDOREDUCTASES 1983-2003, & URACIL 1970-1982
History Note: 2006(1970)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2005/07/11

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0073260
Registry Number: EC 1.3.1.1
Related Numbers: 9026-89-5
Scope Note: An enzyme that catalyzes the oxidation of 5,6-dihydrouracil to URACIL using NAD as a cofactor. This enzyme also plays a role in the catabolism of the antimetabolite 5-FLUOROURACIL.
Terms: Dihydrouracil Dehydrogenase (NAD+) Preferred Term
Term UI T623429
Date12/12/2004
LexicalTag ABX
ThesaurusID NLM (2006); Dihydrouracil Dehydrogenase
Term UI T103263
LexicalTag NON
ThesaurusID NLM (2006); Dihydrouracil Dehydrogenase (NAD)
Term UI T623430
Date12/12/2004
LexicalTag ABX
ThesaurusID NLM (2006); Dihydrothymine Dehydrogenase (NAD)
Term UI T625053
Date12/21/2004
LexicalTag ABX
ThesaurusID NLM (2006)

Dihydrouracil Dehydrogenase (NAD+) MeSH Descriptor Data 2023