MeSH Browser

MeSH Heading: Fluorouracil
Tree Number(s): D03.383.742.698.875.404
Unique ID: D005472
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005472
Scope Note: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
Entry Term(s): 5-FU; 5-FU Lederle; 5-FU Medac; 5-Fluorouracil; 5-Fluorouracil-Biosyn; 5-HU Hexal; 5FU; Adrucil; Carac; Efudex; Efudix; Fluoro-Uracile ICN; Fluoroplex; Fluorouracil Mononitrate; Fluorouracil Monopotassium Salt; Fluorouracil Monosodium Salt; Fluorouracil Potassium Salt; Fluorouracil-GRY; Fluorouracile Dakota; Fluorouracilo Ferrer Far; Fluoruracil; Fluracedyl; Flurodex; Haemato-FU; Neofluor; Onkofluor; Ribofluor
Pharm Action: Antimetabolites
Antimetabolites, Antineoplastic
Immunosuppressive Agents
Related Numbers: 10318-20-4; 51-21-8; 57050-04-1; 57172-36-8; 68021-61-4
CAS Type 1 Name: 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
NLM Classification #: QV 269
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0008631
Related Numbers: 10318-20-4; 51-21-8; 57050-04-1; 57172-36-8; 68021-61-4
Scope Note: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
Terms: Fluorouracil Preferred Term
Term UI T016644
Date01/01/1999
LexicalTag NON
ThesaurusID; 5-Fluorouracil
Term UI T016643
Date12/26/1978
LexicalTag NON
ThesaurusID; Fluoruracil
Term UI T016645
Date12/18/1978
LexicalTag NON
ThesaurusID UNK (19XX); 5-FU
Term UI T476160
Date01/07/2002
LexicalTag ACR
ThesaurusID; 5FU
Term UI T476161
Date01/07/2002
LexicalTag ACR
ThesaurusID NLM (2003)