MeSH Browser

MeSH Heading: Phosphatidylinositol 3-Kinases
Tree Number(s): D08.811.913.696.620.500; D12.776.476.556
Unique ID: D019869
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019869
Annotation: note specifics including PHOSPHATIDYLINOSITOL 3-KINASE are available
Scope Note: Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
Entry Term(s): PI 3-Kinase; PI-3 Kinase; PI-3K; PI3 Kinases; PI3-Kinase; Phosphatidylinositol-3-OH Kinase; Phosphoinositide 3 Kinases; Phosphoinositide 3-Hydroxykinase; PtdIns 3-Kinase; PtdIns 3-Kinases
Registry Numbers: EC 2.7.1.-
Previous Indexing: Phosphotransferases (1988-1993); Phosphotransferases (Alcohol Group Acceptor) (1994-1997)
Public MeSH Note: 2011; see 1-PHOSPHATIDYLINOSITOL 3-KINASE 1998-2010; 1-PHOSPHATIDYLINOSITOL 3-KINASE was indexed under PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR) 1994-97 & PHOSPHOTRANSFERASES, ATP 1988-93
History Note: 2011(1998)
Entry Combination: antagonists & inhibitors:Phosphoinositide-3 Kinase Inhibitors
Date Established: 1998/01/01
Date of Entry: 1997/07/02
Revision Date: 2021/05/21

Entry Combination: antagonists & inhibitors:Phosphoinositide-3 Kinase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Adenosine Kinase [D08.811.913.696.620.010]
        
        Choline Kinase [D08.811.913.696.620.155]
        
        Deoxycytidine Kinase [D08.811.913.696.620.175]
        
        Diacylglycerol Kinase [D08.811.913.696.620.200]
        
        Fructokinases [D08.811.913.696.620.225]
        
        Galactokinase [D08.811.913.696.620.240]
        
        Glucokinase [D08.811.913.696.620.250]
        
        Glycerol Kinase [D08.811.913.696.620.275]
        
        Hexokinase [D08.811.913.696.620.300]
        
        Kanamycin Kinase [D08.811.913.696.620.475]
        
        Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500]
        
        Phosphatidylinositol 3-Kinase [D08.811.913.696.620.500.100]
        
        Phosphatidylinositol-4-Phosphate 3-Kinase [D08.811.913.696.620.500.200]
        
        1-Phosphatidylinositol 4-Kinase [D08.811.913.696.620.550]
        
        Phosphoenolpyruvate Sugar Phosphotransferase System [D08.811.913.696.620.650]
        
        Polynucleotide 5'-Hydroxyl-Kinase [D08.811.913.696.620.680]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Pyridoxal Kinase [D08.811.913.696.620.685]
        
        Pyruvate Kinase [D08.811.913.696.620.695]
        
        Thymidine Kinase [D08.811.913.696.620.750]
        
        Uridine Kinase [D08.811.913.696.620.800]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]

Phosphatidylinositol 3-Kinases Preferred

Concept UI: M0543042
Registry Numbers: EC 2.7.1.-
Scope Note: Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
Terms: Phosphatidylinositol 3-Kinases Preferred Term
Term UI T764745
Date01/26/2010
LexicalTag NON
ThesaurusID NLM (2011); Phosphoinositide 3 Kinases
Term UI T000941530
Date03/26/2018
LexicalTag NON
ThesaurusID NLM (2019); PI3-Kinase
Term UI T059149
Date04/24/1997
LexicalTag NON
ThesaurusID NLM (1998); Phosphatidylinositol-3-OH Kinase
Term UI T059150
Date02/06/1997
LexicalTag NON
ThesaurusID NLM (1998); Phosphoinositide 3-Hydroxykinase
Term UI T059151
Date02/06/1997
LexicalTag NON
ThesaurusID NLM (1998); PI 3-Kinase
Term UI T059153
Date06/11/1997
LexicalTag NON
ThesaurusID NLM (1998); PI-3 Kinase
Term UI T059154
Date02/06/1997
LexicalTag NON
ThesaurusID NLM (1998); PtdIns 3-Kinase
Term UI T059155
Date06/11/1997
LexicalTag NON
ThesaurusID NLM (1998); PI3 Kinases
Term UI T765008
Date01/29/2010
LexicalTag ABX
ThesaurusID NLM (2011); PI-3K
Term UI T059152
Date02/06/1997
LexicalTag ABB
ThesaurusID NLM (1998); PtdIns 3-Kinases
Term UI T765009
Date01/29/2010
LexicalTag ABX
ThesaurusID NLM (2011)

Phosphatidylinositol 3-Kinases MeSH Descriptor Data 2025