MeSH Browser

MeSH Heading: Protein Tyrosine Phosphatases
Tree Number(s): D08.811.277.352.650.775; D12.776.476.564
Unique ID: D017027
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017027
Annotation: general; prefer specifics
Scope Note: An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.
Entry Term(s): PTPase; Phosphotyrosine Phosphatase; Phosphotyrosyl Protein Phosphatase; Protein-Tyrosine Phosphatase; Protein-Tyrosine-Phosphatase; Tyrosyl Phosphoprotein Phosphatase
Registry Numbers: EC 3.1.3.48
Related Numbers: 79747-53-8
CAS Type 1 Name: Protein-tyrosine-phosphate phosphohydrolase
Previous Indexing: Phosphoprotein Phosphatases (1985-1991)
Public MeSH Note: 2008; see PROTEIN-TYROSINE-PHOSPHATASE 1992-2007; PROTEIN-TYROSINE PHOSPHATASE was indexed under PHOSPHOPROTEIN PHOSPHATASES 1985-1991
History Note: 2008(1985)
Date Established: 1992/01/01
Date of Entry: 1991/05/30
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Monoester Hydrolases [D08.811.277.352.650]
        
        Acid Phosphatase [D08.811.277.352.650.025]
        
        ADP-Ribose 1''-Phosphate Phosphatases [D08.811.277.352.650.030]
        
        Alkaline Phosphatase [D08.811.277.352.650.035]
        
        Fructose-Bisphosphatase [D08.811.277.352.650.200]
        
        Glucose-6-Phosphatase [D08.811.277.352.650.225]
        
        Histidinol-Phosphatase [D08.811.277.352.650.300]
        
        4-Nitrophenylphosphatase [D08.811.277.352.650.575]
        
        Mitogen-Activated Protein Kinase Phosphatases [D08.811.277.352.650.587]
        
        Nucleotidases [D08.811.277.352.650.600]
        
        Phosphatidate Phosphatase [D08.811.277.352.650.620]
        
        Phosphofructokinase-2 [D08.811.277.352.650.622]
        
        Phosphoinositide Phosphatases [D08.811.277.352.650.624]
        
        Phosphoprotein Phosphatases [D08.811.277.352.650.625]
        
        6-Phytase [D08.811.277.352.650.700]
        
        Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
        
        Dual-Specificity Phosphatases [D08.811.277.352.650.775.250]
        
        Protein Tyrosine Phosphatases, Non-Receptor [D08.811.277.352.650.775.300]
        
        Receptor-Like Protein Tyrosine Phosphatases [D08.811.277.352.650.775.400]
        
        SH2 Domain-Containing Protein Tyrosine Phosphatases [D08.811.277.352.650.775.700]
        
        PTEN Phosphohydrolase [D08.811.277.352.650.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]

Protein Tyrosine Phosphatases Preferred

Concept UI: M0025868
Registry Numbers: EC 3.1.3.48
Related Numbers: 79747-53-8
Scope Note: An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.
Terms: Protein Tyrosine Phosphatases Preferred Term
Term UI T690438
Date01/30/2007
LexicalTag NON
ThesaurusID NLM (2008); Phosphotyrosine Phosphatase
Term UI T050825
Date04/03/1991
LexicalTag NON
ThesaurusID NLM (1992); Phosphotyrosyl Protein Phosphatase
Term UI T050826
Date04/03/1991
LexicalTag NON
ThesaurusID NLM (1992); PTPase
Term UI T050829
Date04/03/1991
LexicalTag NON
ThesaurusID NLM (1992); Protein-Tyrosine-Phosphatase
Term UI T050828
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1992); Tyrosyl Phosphoprotein Phosphatase
Term UI T050831
Date04/03/1991
LexicalTag NON
ThesaurusID NLM (1992); Protein-Tyrosine Phosphatase
Term UI T050827
Date04/03/1991
LexicalTag NON
ThesaurusID NLM (1992)

Protein Tyrosine Phosphatases MeSH Descriptor Data 2025