MeSH Browser

MeSH Heading: Phosphofructokinase-2
Tree Number(s): D08.811.277.352.650.622; D08.811.641.843; D08.811.913.696.620.225.850.750
Unique ID: D025481
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D025481
Scope Note: An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
Entry Term(s): 6-PF-2-K-Fru-2,6-P(2)ase; 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase; 6-Phosphofructo-2-kinase; 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase; 6PF2K; ATP-D-Fructose-6-phosphate 2-phosphotransferase; F Kinase-F-bisphosphatase; Fru-6-P,2-kinase; Fru-kinase-Fru-bisphosphatase; Fructose 2,6-bisphosphatase; Fructose-2,6-bisphosphatase; Fructose-2,6-bisphosphate 2-phosphatase; Fructose-6-P,2-kinase; Fructose-6-phosphate,2-kinase; Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase; fructose-2,6-diphosphatase
Related Numbers: EC 3.1.3.46
Previous Indexing: Phosphofructokinase-1 (1981-2001); Phosphoric Monoester Hydrolases (1983-2001); Phosphotransferases (1981-2001)
See Also: Phosphofructokinase-1
Public MeSH Note: 2002; 6-PHOSPHOFRUCTO-2-KINASE was indexed under PHOSPHOTRANSFERASES (NM) 1993-2001, under PHOSPHOTRANSFERASES, ATP (NM) 1981-1993; FRUCTOSE-2,6-BISPHOSPATASE was indexed under PHOSPHORIC MONOESTER HYDROLASES (NM) 1983-2001; 6-PHOSPHOFRUCTO-2-KINASE-FRUCTOSE-2,6-BISPHOSPHATASE was indexed under FRUCTOSE-BISPHOSPHATASE (NM) 1990-2001, under MULTIENZYME COMPLEXES (NM) 1990-2001, under PHOSPHOFRUCTOKINASE-1 (NM) 1990-2001
History Note: 2002; for 6-PHOSPHOFRUCTO-2-KINASE use PHOSPHOTRANSFERASES (NM) 1993-2001, use PHOSPHOTRANSFERASES, ATP (NM) 1981-1993; for FRUCTOSE-2,6-BISPHOSPATASE use PHOSPHORIC MONOESTER HYDROLASES (NM) 1983-2001; for 6-PHOSPHOFRUCTO-2-KINASE-FRUCTOSE-2,6-BISPHOSPHATASE use FRUCTOSE-BISPHOSPHATASE (NM) 1990-2001, use MULTIENZYME COMPLEXES (NM) 1990-2001, use PHOSPHOFRUCTOKINASE-1 (NM) 1990-2001
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Monoester Hydrolases [D08.811.277.352.650]
        
        Acid Phosphatase [D08.811.277.352.650.025]
        
        ADP-Ribose 1''-Phosphate Phosphatases [D08.811.277.352.650.030]
        
        Alkaline Phosphatase [D08.811.277.352.650.035]
        
        Fructose-Bisphosphatase [D08.811.277.352.650.200]
        
        Glucose-6-Phosphatase [D08.811.277.352.650.225]
        
        Histidinol-Phosphatase [D08.811.277.352.650.300]
        
        4-Nitrophenylphosphatase [D08.811.277.352.650.575]
        
        Mitogen-Activated Protein Kinase Phosphatases [D08.811.277.352.650.587]
        
        Nucleotidases [D08.811.277.352.650.600]
        
        Phosphatidate Phosphatase [D08.811.277.352.650.620]
        
        Phosphofructokinase-2 [D08.811.277.352.650.622]
        
        Phosphoinositide Phosphatases [D08.811.277.352.650.624]
        
        Phosphoprotein Phosphatases [D08.811.277.352.650.625]
        
        6-Phytase [D08.811.277.352.650.700]
        
        Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
        
        PTEN Phosphohydrolase [D08.811.277.352.650.850]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Multifunctional Enzymes [D08.811.641]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Fructokinases [D08.811.913.696.620.225]
        
        Phosphofructokinases [D08.811.913.696.620.225.850]
        
        Phosphofructokinase-1 [D08.811.913.696.620.225.850.500]
        
        Phosphofructokinase-2 [D08.811.913.696.620.225.850.750]

Phosphofructokinase-2 Preferred

Concept UI: M0374774
Related Numbers: EC 3.1.3.46
Scope Note: An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
Terms: Phosphofructokinase-2 Preferred Term
Term UI T431251
Date12/18/2000
LexicalTag NON
ThesaurusID NLM (2002); 6PF2K
Term UI T137083
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (2002); 6-Phosphofructo-2-kinase
Term UI T137088
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Fru-6-P,2-kinase
Term UI T137085
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); Fructose-6-P,2-kinase
Term UI T137086
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); Fructose-6-phosphate,2-kinase
Term UI T137087
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); ATP-D-Fructose-6-phosphate 2-phosphotransferase
Term UI T137084
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002)

Fructose-2,6-bisphosphatase Narrower

6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase Broader

Phosphofructokinase-2 MeSH Descriptor Data 2025