MeSH Browser

MeSH Heading: Peroxisomal Multifunctional Protein-2
Tree Number(s): D08.811.520.241.300.275.500; D08.811.641.812; D08.811.682.047.436.375.640; D08.811.682.047.820.150.926
Unique ID: D064029
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064029
Scope Note: A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.
Entry Term(s): 17-beta-Hydroxysteroid Dehydrogenase 4; 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase; Peroxisomal Multifunctional Enzyme Type 2
Related Numbers: EC 1.1.1.-; EC 4.2.1.119
Previous Indexing: 17-Hydroxysteroid Dehydrogenases (1997-2013); Enoyl-CoA Hydratase (1997-2013)
Public MeSH Note: 2014
History Note: 2014
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0579232
Related Numbers: EC 1.1.1.-; EC 4.2.1.119
Scope Note: A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.
Terms: Peroxisomal Multifunctional Protein-2 Preferred Term
Term UI T833570
Date11/28/2012
LexicalTag NON
ThesaurusID NLM (2014); 17-beta-Hydroxysteroid Dehydrogenase 4
Term UI T833633
Date11/29/2012
LexicalTag NON
ThesaurusID NLM (2014); 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
Term UI T833634
Date11/29/2012
LexicalTag NON
ThesaurusID NLM (2014); Peroxisomal Multifunctional Enzyme Type 2
Term UI T833632
Date11/29/2012
LexicalTag NON
ThesaurusID NLM (2014)

Peroxisomal Multifunctional Protein-2 MeSH Descriptor Data 2025