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Peroxisomal Multifunctional Protein-2 MeSH Descriptor Data 2023


MeSH Heading
Peroxisomal Multifunctional Protein-2
Tree Number(s)
D08.811.520.241.300.275.500
D08.811.641.812
D08.811.682.047.436.375.640
D08.811.682.047.820.150.926
Unique ID
D064029
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D064029
Scope Note
A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.
Entry Term(s)
17-beta-Hydroxysteroid Dehydrogenase 4
3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
Peroxisomal Multifunctional Enzyme Type 2
Registry Number
EC 4.2.1.107
Related Numbers
EC 1.1.1.-
EC 4.2.1.119
Previous Indexing
17-Hydroxysteroid Dehydrogenases (1997-2013)
Enoyl-CoA Hydratase (1997-2013)
Public MeSH Note
2014
History Note
2014
Date Established
2014/01/01
Date of Entry
2013/07/08
Peroxisomal Multifunctional Protein-2 Preferred
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