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Lactase-Phlorizin Hydrolase MeSH Descriptor Data 2023


MeSH Heading
Lactase-Phlorizin Hydrolase
Tree Number(s)
D08.811.277.450.410.100.500.500
D08.811.277.450.420.475
D08.811.641.761
Unique ID
D010694
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D010694
Scope Note
A multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. The second domain (EC 3.2.1.108) hydrolyzes LACTOSE and is found in the intestinal brush border membrane. Loss of activity for this enzyme in humans results in LACTOSE INTOLERANCE.
Entry Term(s)
Glycosyl Ceramidase
Glycosylceramidase
Lactase-Glycosylceramidase
Phloretin-Glucosidase
Phlorizin Hydrolase
Registry Number
EC 3.2.1.62
Related Numbers
EC 3.2.1.108
Previous Indexing
Glucosidases (1966-1977)
See Also
Lactose Intolerance
Public MeSH Note
2014; see GLYCOSYLCERAMIDASE 1992-2013, see PHLORETIN GLUCOSIDASE 1978-1991, see PHLORETIN GLUCOSIDASE 1978-1993
History Note
2014 (1992)
Date Established
1991/01/01
Date of Entry
1977/04/15
Revision Date
2018/05/21
Lactase-Phlorizin Hydrolase Preferred
Phloretin-Glucosidase Related
Phlorizin Hydrolase Narrower
Glycosyl Ceramidase Related
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