MeSH Browser

MeSH Heading: Glucosylceramidase
Tree Number(s): D08.811.277.450.420.412
Unique ID: D005962
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005962
Annotation: /defic: consider also GAUCHER DISEASE
Scope Note: A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high concentrations of glucosylceramide in the brain in GAUCHER DISEASE. EC 3.2.1.45.
Entry Term(s): Acid beta-Glucosidase; Glucocerebrosidase; Glucocerebroside beta-Glucosidase; Glucosyl Ceramidase; Glucosylceramide beta-Glucosidase; Glucosylsphingosine Glucosyl Hydrolase; beta-Glucocerebrosidase
CAS Type 1 Name: D-Glucosyl-N-acylsphingosine glucosylhydrolase
Previous Indexing: Cerebrosides (1970-1974); Glucose (1970-1974); Glycoside Hydrolases (1970-1974)
See Also: Gaucher Disease
Public MeSH Note: 91; was see under GLUCOSIDASES 1975-90
History Note: 91(75); was see under GLUCOSIDASES 1975-90
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0009360
Scope Note: A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high concentrations of glucosylceramide in the brain in GAUCHER DISEASE. EC 3.2.1.45.
Terms: Glucosylceramidase Preferred Term
Term UI T018060
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Glucosyl Ceramidase
Term UI T018064
Date01/04/1991
LexicalTag NON
ThesaurusID NLM (1992); beta-Glucocerebrosidase
Term UI T018057
Date05/19/1982
LexicalTag NON
ThesaurusID UNK (19XX); Glucocerebrosidase
Term UI T018058
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Glucocerebroside beta-Glucosidase
Term UI T018059
Date02/04/1982
LexicalTag NON
ThesaurusID UNK (19XX); Glucosylceramide beta-Glucosidase
Term UI T018061
Date11/29/1982
LexicalTag NON
ThesaurusID UNK (19XX); Glucosylsphingosine Glucosyl Hydrolase
Term UI T018062
Date05/28/1985
LexicalTag NON
ThesaurusID UNK (19XX); Acid beta-Glucosidase
Term UI T018063
Date11/02/1990
LexicalTag NON
ThesaurusID NLM (1992)

Glucosylceramidase MeSH Descriptor Data 2025