MeSH Browser

MeSH Heading: Aldo-Keto Reductase Family 1 Member C3
Tree Number(s): D08.811.682.047.150.700.156.875; D08.811.682.047.436.375.140; D08.811.682.047.820.284.937; D08.811.682.047.820.375.500
Unique ID: D000074425
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074425
Scope Note: Aldo-keto reductase that functions as a bi-directional 17 BETA, 20 ALPHA-HYDROXYSTEROID DEHYDROGENASE. It catalyzes the reduction of PROSTAGLANDIN D2 and PROSTAGLANDIN H2, as well as the oxidation of 9alpha,11beta-PGF2 to prostaglandin D2. It can also interconvert estrogens, ANDROGENS; and PROGESTINS between their active forms and inactive metabolites.
Entry Term(s): 17-beta-Hydroxysteroid Dehydrogenase Type 5; AKR1C3 Protein; Dihydrodiol Dehydrogenase 3
Registry Numbers: EC 1.1.1.357
Previous Indexing: 3-Hydroxysteroid Dehydrogenases (2004-2017); Hydroxyprostaglandin Dehydrogenases (2004-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000626540
Registry Numbers: EC 1.1.1.357
Scope Note: Aldo-keto reductase that functions as a bi-directional 17 BETA, 20 ALPHA-HYDROXYSTEROID DEHYDROGENASE. It catalyzes the reduction of PROSTAGLANDIN D2 and PROSTAGLANDIN H2, as well as the oxidation of 9alpha,11beta-PGF2 to prostaglandin D2. It can also interconvert estrogens, ANDROGENS; and PROGESTINS between their active forms and inactive metabolites.
Terms: Aldo-Keto Reductase Family 1 Member C3 Preferred Term
Term UI T000915870
Date02/16/2017
LexicalTag NON
ThesaurusID NLM (2018); Dihydrodiol Dehydrogenase 3
Term UI T000915871
Date02/16/2017
LexicalTag NON
ThesaurusID NLM (2018); 17-beta-Hydroxysteroid Dehydrogenase Type 5
Term UI T000915872
Date02/16/2017
LexicalTag NON
ThesaurusID NLM (2018); AKR1C3 Protein
Term UI T000915873
Date02/16/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Aldo-Keto Reductase Family 1 Member C3 MeSH Descriptor Data 2025