MeSH Browser

MeSH Heading: Aldo-Keto Reductases
Tree Number(s): D08.811.682.047.150.700.156; D08.811.682.047.820.284
Unique ID: D000074408
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074408
Scope Note: A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.
Entry Term(s): Aldo-Keto Reductase; Aldo-Keto Reductase Family; Aldo-Keto Reductase Superfamily
Registry Number: EC 1.1.1.-
Previous Indexing: Aldehyde Reductase (1976-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/06

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Alcohol Oxidoreductases [D08.811.682.047]
      - Carbohydrate Dehydrogenases [D08.811.682.047.150]
        
        Sugar Alcohol Dehydrogenases [D08.811.682.047.150.700]
        
        Aldo-Keto Reductases [D08.811.682.047.150.700.156]
        
        Aldehyde Reductase [D08.811.682.047.150.700.156.500]
        
        Aldo-Keto Reductase Family 1 member B10 [D08.811.682.047.150.700.156.625]
        
        Aldo-Keto Reductase Family 1 Member C2 [D08.811.682.047.150.700.156.750]
        
        Aldo-Keto Reductase Family 1 Member C3 [D08.811.682.047.150.700.156.875]
        
        20-alpha-Hydroxysteroid Dehydrogenase [D08.811.682.047.150.700.156.937]
        
        D-Xylulose Reductase [D08.811.682.047.150.700.237]
        
        Glycerolphosphate Dehydrogenase [D08.811.682.047.150.700.400]
        
        L-Gulonolactone Oxidase [D08.811.682.047.150.700.437]
        
        L-Iditol 2-Dehydrogenase [D08.811.682.047.150.700.475]
        
        Mannitol Dehydrogenases [D08.811.682.047.150.700.649]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Alcohol Oxidoreductases [D08.811.682.047]
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases [D08.811.682.047.820]
        
        11-beta-Hydroxysteroid Dehydrogenases [D08.811.682.047.820.100]
        
        20-Hydroxysteroid Dehydrogenases [D08.811.682.047.820.125]
        
        3-Hydroxyacyl CoA Dehydrogenases [D08.811.682.047.820.150]
        
        3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) [D08.811.682.047.820.186]
        
        3-Isopropylmalate Dehydrogenase [D08.811.682.047.820.193]
        
        3-Oxoacyl-(Acyl-Carrier-Protein) Reductase [D08.811.682.047.820.196]
        
        Acetoin Dehydrogenase [D08.811.682.047.820.200]
        
        Alcohol Dehydrogenase [D08.811.682.047.820.250]
        
        Aldo-Keto Reductases [D08.811.682.047.820.284]
        
        Aldehyde Reductase [D08.811.682.047.820.284.500]
        
        20-alpha-Hydroxysteroid Dehydrogenase [D08.811.682.047.820.284.750]
        
        Aldo-Keto Reductase Family 1 member B10 [D08.811.682.047.820.284.813]
        
        Aldo-Keto Reductase Family 1 Member C2 [D08.811.682.047.820.284.875]
        
        Aldo-Keto Reductase Family 1 Member C3 [D08.811.682.047.820.284.937]
        
        Carbonyl Reductase (NADPH) [D08.811.682.047.820.289]
        
        Glycerol-3-Phosphate Dehydrogenase (NAD+) [D08.811.682.047.820.293]
        
        Homoserine Dehydrogenase [D08.811.682.047.820.300]
        
        Hydroxybutyrate Dehydrogenase [D08.811.682.047.820.350]
        
        Hydroxyprostaglandin Dehydrogenases [D08.811.682.047.820.375]
        
        Hydroxypyruvate Reductase [D08.811.682.047.820.400]
        
        IMP Dehydrogenase [D08.811.682.047.820.450]
        
        Isocitrate Dehydrogenase [D08.811.682.047.820.475]
        
        Ketol-Acid Reductoisomerase [D08.811.682.047.820.487]
        
        L-Lactate Dehydrogenase [D08.811.682.047.820.493]
        
        Malate Dehydrogenase [D08.811.682.047.820.496]
        
        Malate Dehydrogenase (NADP+) [D08.811.682.047.820.498]
        
        Progesterone Reductase [D08.811.682.047.820.500]
        
        D-Xylulose Reductase [D08.811.682.047.820.800]
        
        Short Chain Dehydrogenase-Reductases [D08.811.682.047.820.900]

Aldo-Keto Reductases Preferred

Concept UI: M000626517
Registry Number: EC 1.1.1.-
Scope Note: A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.
Terms: Aldo-Keto Reductases Preferred Term
Term UI T000915814
Date02/14/2017
LexicalTag NON
ThesaurusID NLM (2018); Aldo-Keto Reductase Superfamily
Term UI T000915841
Date02/15/2017
LexicalTag NON
ThesaurusID NLM (2018); Aldo-Keto Reductase Family
Term UI T000915840
Date02/15/2017
LexicalTag NON
ThesaurusID NLM (2018)

Aldo-Keto Reductase Narrower

Aldo-Keto Reductases MeSH Descriptor Data 2023