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Isocitrate Dehydrogenase MeSH Descriptor Data 2021


MeSH Heading
Isocitrate Dehydrogenase
Tree Number(s)
D08.811.682.047.820.475
Unique ID
D007521
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007521
Scope Note
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Entry Term(s)
Isocitrate Dehydrogenase (NAD+)
Isocitrate Dehydrogenase-I
NAD Isocitrate Dehydrogenase
Registry Number
EC 1.1.1.41
CAS Type 1 Name
Isocitrate:NAD+ oxidoreductase (decarboxylating)
Public MeSH Note
65
History Note
65(63)
Date Established
1965/01/01
Date of Entry
1999/01/01
Revision Date
2013/07/08
Isocitrate Dehydrogenase Preferred
Isocitrate Dehydrogenase-I Narrower
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