MeSH Browser

MeSH Heading: Isocitrate Dehydrogenase
Tree Number(s): D08.811.682.047.820.475
Unique ID: D007521
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007521
Scope Note: An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Entry Term(s): Isocitrate Dehydrogenase (NAD+); Isocitrate Dehydrogenase-I; NAD Isocitrate Dehydrogenase
CAS Type 1 Name: Isocitrate:NAD+ oxidoreductase (decarboxylating)
Public MeSH Note: 65
History Note: 65(63)
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Alcohol Oxidoreductases [D08.811.682.047]
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases [D08.811.682.047.820]
        
        11-beta-Hydroxysteroid Dehydrogenases [D08.811.682.047.820.100]
        
        20-Hydroxysteroid Dehydrogenases [D08.811.682.047.820.125]
        
        3-Hydroxyacyl CoA Dehydrogenases [D08.811.682.047.820.150]
        
        3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) [D08.811.682.047.820.186]
        
        3-Isopropylmalate Dehydrogenase [D08.811.682.047.820.193]
        
        3-Oxoacyl-(Acyl-Carrier-Protein) Reductase [D08.811.682.047.820.196]
        
        Acetoin Dehydrogenase [D08.811.682.047.820.200]
        
        Alcohol Dehydrogenase [D08.811.682.047.820.250]
        
        Aldo-Keto Reductases [D08.811.682.047.820.284]
        
        Carbonyl Reductase (NADPH) [D08.811.682.047.820.289]
        
        Glycerol-3-Phosphate Dehydrogenase (NAD+) [D08.811.682.047.820.293]
        
        Homoserine Dehydrogenase [D08.811.682.047.820.300]
        
        Hydroxybutyrate Dehydrogenase [D08.811.682.047.820.350]
        
        Hydroxyprostaglandin Dehydrogenases [D08.811.682.047.820.375]
        
        Hydroxypyruvate Reductase [D08.811.682.047.820.400]
        
        IMP Dehydrogenase [D08.811.682.047.820.450]
        
        Isocitrate Dehydrogenase [D08.811.682.047.820.475]
        
        Ketol-Acid Reductoisomerase [D08.811.682.047.820.487]
        
        L-Lactate Dehydrogenase [D08.811.682.047.820.493]
        
        Malate Dehydrogenase [D08.811.682.047.820.496]
        
        Malate Dehydrogenase (NADP+) [D08.811.682.047.820.498]
        
        Progesterone Reductase [D08.811.682.047.820.500]
        
        D-Xylulose Reductase [D08.811.682.047.820.800]
        
        Short Chain Dehydrogenase-Reductases [D08.811.682.047.820.900]

Isocitrate Dehydrogenase Preferred

Concept UI: M0011751
Scope Note: An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Terms: Isocitrate Dehydrogenase Preferred Term
Term UI T022611
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1963); Isocitrate Dehydrogenase (NAD+)
Term UI T022612
Date11/02/1990
LexicalTag NON
ThesaurusID NLM (1992); NAD Isocitrate Dehydrogenase
Term UI T022613
Date11/02/1990
LexicalTag NON
ThesaurusID NLM (1992)

Isocitrate Dehydrogenase-I Narrower

Isocitrate Dehydrogenase MeSH Descriptor Data 2025