MeSH Browser

MeSH Heading: Ketol-Acid Reductoisomerase
Tree Number(s): D08.811.682.047.820.487
Unique ID: D050540
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050540
Scope Note: An enzyme that catalyzes the oxidation of (R)-2,3-dihydroxy-3-methylbutanoate to (S)-2-hydroxy-2-methyl-3-oxobutanoate in the presence of NADP. It is involved in the biosynthesis of VALINE; LEUCINE; ISOLEUCINE; pentothenate and COENZYME A. This enzyme was formerly classified as EC 1.1.1.89.
Entry Term(s): Acetohydroxy Acid Isomeroreductase; Alpha-Acetohydroxyacid Isomeroreductase; Dihydroxyisovalerate Dehydrogenase (Isomerizing); Hydroxyacid Reductoisomerase; Isomeroreductase
Related Numbers: 9075-02-9
Public MeSH Note: 2006; KETOL-ACID REDUCTOISOMERASE was indexed under ALCOHOL OXODOREDUCTASES 1983-2000, & under VALERATES 1970-1982
History Note: 2006(1980); use VALERATES 1970-1979
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Alcohol Oxidoreductases [D08.811.682.047]
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases [D08.811.682.047.820]
        
        11-beta-Hydroxysteroid Dehydrogenases [D08.811.682.047.820.100]
        
        20-Hydroxysteroid Dehydrogenases [D08.811.682.047.820.125]
        
        3-Hydroxyacyl CoA Dehydrogenases [D08.811.682.047.820.150]
        
        3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) [D08.811.682.047.820.186]
        
        3-Isopropylmalate Dehydrogenase [D08.811.682.047.820.193]
        
        3-Oxoacyl-(Acyl-Carrier-Protein) Reductase [D08.811.682.047.820.196]
        
        Acetoin Dehydrogenase [D08.811.682.047.820.200]
        
        Alcohol Dehydrogenase [D08.811.682.047.820.250]
        
        Aldo-Keto Reductases [D08.811.682.047.820.284]
        
        Carbonyl Reductase (NADPH) [D08.811.682.047.820.289]
        
        Glycerol-3-Phosphate Dehydrogenase (NAD+) [D08.811.682.047.820.293]
        
        Homoserine Dehydrogenase [D08.811.682.047.820.300]
        
        Hydroxybutyrate Dehydrogenase [D08.811.682.047.820.350]
        
        Hydroxyprostaglandin Dehydrogenases [D08.811.682.047.820.375]
        
        Hydroxypyruvate Reductase [D08.811.682.047.820.400]
        
        IMP Dehydrogenase [D08.811.682.047.820.450]
        
        Isocitrate Dehydrogenase [D08.811.682.047.820.475]
        
        Ketol-Acid Reductoisomerase [D08.811.682.047.820.487]
        
        L-Lactate Dehydrogenase [D08.811.682.047.820.493]
        
        Malate Dehydrogenase [D08.811.682.047.820.496]
        
        Malate Dehydrogenase (NADP+) [D08.811.682.047.820.498]
        
        Progesterone Reductase [D08.811.682.047.820.500]
        
        D-Xylulose Reductase [D08.811.682.047.820.800]
        
        Short Chain Dehydrogenase-Reductases [D08.811.682.047.820.900]

Ketol-Acid Reductoisomerase Preferred

Concept UI: M0076427
Related Numbers: 9075-02-9
Scope Note: An enzyme that catalyzes the oxidation of (R)-2,3-dihydroxy-3-methylbutanoate to (S)-2-hydroxy-2-methyl-3-oxobutanoate in the presence of NADP. It is involved in the biosynthesis of VALINE; LEUCINE; ISOLEUCINE; pentothenate and COENZYME A. This enzyme was formerly classified as EC 1.1.1.89.
Terms: Ketol-Acid Reductoisomerase Preferred Term
Term UI T106430
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Acetohydroxy Acid Isomeroreductase
Term UI T106425
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Alpha-Acetohydroxyacid Isomeroreductase
Term UI T106426
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Dihydroxyisovalerate Dehydrogenase (Isomerizing)
Term UI T106427
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Hydroxyacid Reductoisomerase
Term UI T106428
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Isomeroreductase
Term UI T106429
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006)

Ketol-Acid Reductoisomerase MeSH Descriptor Data 2025