MeSH Browser

MeSH Heading: Axin Signaling Complex
Tree Number(s): D05.500.117; D12.776.476.081
Unique ID: D060465
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D060465
Scope Note: A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.
Entry Term(s): Axin Signaling Complex Proteins; beta-Catenin Destruction Complex
Public MeSH Note: 2012
History Note: 2012
Date Established: 2012/01/01
Date of Entry: 2011/06/24
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Axin Signaling Complex MeSH Descriptor Data 2025