Glycogen Synthase Kinase 3 MeSH Descriptor Data 2025

MeSH Heading: Glycogen Synthase Kinase 3
Tree Number(s): D05.500.117.875; D08.811.913.696.620.682.700.429.500; D08.811.913.696.620.682.700.646.625; D12.776.476.081.875; D12.776.476.563.429.500; D12.776.476.563.646.625
Unique ID: D038362
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D038362
Scope Note: A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.
Entry Term(s): GSK-3; gsk-3 Gene Product
Previous Indexing: Ca(2+)-Calmodulin Dependent Protein Kinase (1995-2002)
Public MeSH Note: 2003; GLYCOGEN SYNTEHASE KINASE 3 was indexed under CA(2+)-CALMODULIN PROTEIN KINASE 1995-2002
History Note: 2003; use GLYCOGEN SYNTHASE KINASE 3 (NM) 1995-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Macromolecular Substances [D05]
- Multiprotein Complexes [D05.500]
  - Axin Signaling Complex [D05.500.117]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]
        
        Glycogen Synthase Kinase 3 [D08.811.913.696.620.682.700.429.500]
        
        Glycogen Synthase Kinase 3 beta [D08.811.913.696.620.682.700.429.500.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
        
        Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
        
        Glycogen Synthase Kinase 3 [D08.811.913.696.620.682.700.646.625]
        
        Glycogen Synthase Kinase 3 beta [D08.811.913.696.620.682.700.646.625.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Axin Signaling Complex [D12.776.476.081]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Glycogen Synthase Kinases [D12.776.476.563.429]
        
        Glycogen Synthase Kinase 3 [D12.776.476.563.429.500]
        
        Glycogen Synthase Kinase 3 beta [D12.776.476.563.429.500.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Proline-Directed Protein Kinases [D12.776.476.563.646]
        
        Cyclin-Dependent Kinases [D12.776.476.563.646.500]
        
        Glycogen Synthase Kinase 3 [D12.776.476.563.646.625]
        
        Glycogen Synthase Kinase 3 beta [D12.776.476.563.646.625.500]

Glycogen Synthase Kinase 3 Preferred

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