MeSH Browser

MeSH Heading: Shelterin Complex
Tree Number(s): A11.284.430.106.279.345.190.160.845.500; D05.500.918; D12.776.260.735.625; D12.776.660.235.700.625; D12.776.664.981; G05.360.160.845.500
Unique ID: D000089804
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000089804
Scope Note: A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).
Entry Term(s): CST Complex; Ctc1-Stn1-Ten1 Complex; POT1-TPP1 Shelterin Complex; Telomere Cap Complex; Telomere POT1-TPP1 Complex; Telomeric Capping Complex; Telomeric Stn1-Ten1 Capping Complex; Telosome
Previous Indexing: Telomere-Binding Proteins (2005-2021)
Public MeSH Note: 2022
History Note: 2022
Date Established: 2022/01/01
Date of Entry: 2021/07/09
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000744989
Scope Note: A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).
Terms: Shelterin Complex Preferred Term
Term UI T001102209
Date03/10/2021
LexicalTag NON
ThesaurusID NLM (2022); Telomere POT1-TPP1 Complex
Term UI T001102213
Date03/10/2021
LexicalTag NON
ThesaurusID NLM (2022); Telosome
Term UI T001102217
Date03/10/2021
LexicalTag NON
ThesaurusID NLM (2022); POT1-TPP1 Shelterin Complex
Term UI T001102216
Date03/10/2021
LexicalTag NON
ThesaurusID NLM (2022)

Shelterin Complex MeSH Descriptor Data 2025