MeSH Browser

MeSH Heading: Mitochondrial Precursor Protein Import Complex Proteins
Tree Number(s): D05.500.469; D05.500.890.563; D12.776.543.585.475.594; D12.776.575.750.594
Unique ID: D000090622
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000090622
Scope Note: Multiprotein complexes that mediate import and sorting of mitochondrial preproteins into one of the four mitochondrial subcompartments: the outer membrane, the intermembrane space, the inner membrane, and the matrix. Mitochondrial protein import machinery includes translocase of the outer membrane (TOM) complex, translocases of the inner membrane (TIM) complex, beta‐barrel pathway complex, the mitochondrial intermembrane space import and assembly (MIA) pathway complex, carrier proteins of the inner membrane and the TIM23 complex and sorting and assembly machinery (SAM) complex.
Entry Term(s): MIA Complex; MIM Complex; Mitochondrial Import Complex; Mitochondrial Intermembrane Space Import and Assembly Complex; Mitochondrial Precursor Protein Import Machinery Proteins; Mitochondrial Preprotein Translocases; Mitochondrial Protein Import Machinery Proteins; SAM Complex; Sorting and Assembly Machinery Complex; TIM Complex; TIM23 Complex; TIMM Complex; TOM Channel; TOM Complex; TOM Translocase; TOMM Complex; TOMM Machinery; Translocase Outer Mitochondrial Membrane; Translocase of the Inner Membrane Complex; Translocase of the Inner Mitochondrial Membrane Complex; Translocase of the Outer Membrane Complex; Translocases of the Inner Membrane 23 Complex; Translocases of the Inner Membrane Complex
Registry Number: 0
Public MeSH Note: 2022; for TOM COMPLEX see CARRIER PROTEINS 2006-2021
History Note: 2022(2006)
Date Established: 2022/01/01
Date of Entry: 2021/07/09
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Macromolecular Substances [D05]
- Multiprotein Complexes [D05.500]

Macromolecular Substances [D05]
- Multiprotein Complexes [D05.500]
  - Protein Translocation Systems [D05.500.890]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Mitochondrial Membrane Transport Proteins [D12.776.543.585.475]
        
        Mitochondrial ADP, ATP Translocases [D12.776.543.585.475.500]
        
        Mitochondrial Permeability Transition Pore [D12.776.543.585.475.563]
        
        Mitochondrial Precursor Protein Import Complex Proteins [D12.776.543.585.475.594]
        
        Mitochondrial Proton-Translocating ATPases [D12.776.543.585.475.625]
        
        Mitochondrial Uncoupling Proteins [D12.776.543.585.475.688]
        
        Voltage-Dependent Anion Channel 1 [D12.776.543.585.475.750]
        
        Voltage-Dependent Anion Channel 2 [D12.776.543.585.475.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Mitochondrial Proteins [D12.776.575]
    - Mitochondrial Membrane Transport Proteins [D12.776.575.750]

Mitochondrial Precursor Protein Import Complex Proteins Preferred

Concept UI: M000746905
Registry Number: 0
Scope Note: Multiprotein complexes that mediate import and sorting of mitochondrial preproteins into one of the four mitochondrial subcompartments: the outer membrane, the intermembrane space, the inner membrane, and the matrix. Mitochondrial protein import machinery includes translocase of the outer membrane (TOM) complex, translocases of the inner membrane (TIM) complex, beta‐barrel pathway complex, the mitochondrial intermembrane space import and assembly (MIA) pathway complex, carrier proteins of the inner membrane and the TIM23 complex and sorting and assembly machinery (SAM) complex.
Terms: Mitochondrial Precursor Protein Import Complex Proteins Preferred Term
Term UI T001107368
Date06/01/2021
LexicalTag NON
ThesaurusID NLM (2022); Mitochondrial Protein Import Machinery Proteins
Term UI T001104525
Date04/13/2021
LexicalTag NON
ThesaurusID NLM (2022); Mitochondrial Precursor Protein Import Machinery Proteins
Term UI T001104511
Date04/13/2021
LexicalTag NON
ThesaurusID NLM (2022)

Mitochondrial Preprotein Translocases Narrower

Mitochondrial Intermembrane Space Import and Assembly Complex Narrower

Translocase of the Outer Membrane Complex Narrower

Sorting and Assembly Machinery Complex Narrower

Mitochondrial Import Complex Narrower

TOM Complex Narrower

Concept UI: M0468589
Registry Number: 0
Terms: TOM Complex Preferred Term
Term UI T001104491
Date04/13/2021
LexicalTag ACX
ThesaurusID NLM (2004); TOMM Complex
Term UI T001104501
Date04/13/2021
LexicalTag NON
ThesaurusID NLM (2022); TOMM Machinery
Term UI T001104524
Date04/13/2021
LexicalTag ACX
ThesaurusID NLM (2022); Translocase Outer Mitochondrial Membrane
Term UI T001104500
Date04/13/2021
LexicalTag NON
ThesaurusID NLM (2022); TOM Translocase
Term UI T001104492
Date04/13/2021
LexicalTag ACX
ThesaurusID NLM (2004); TOM Channel
Term UI T001104493
Date04/13/2021
LexicalTag NON
ThesaurusID NLM (2022)

Translocases of the Inner Membrane Complex Narrower

Translocases of the Inner Membrane 23 Complex Narrower

Mitochondrial Precursor Protein Import Complex Proteins MeSH Descriptor Data 2023