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COP9 Signalosome Complex MeSH Descriptor Data 2025


MeSH Heading
COP9 Signalosome Complex
Tree Number(s)
D05.500.139
D08.811.037.750.250
D08.811.277.656.300.887.375
Unique ID
D000075686
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000075686
Scope Note
A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.
Entry Term(s)
COP9 Signalosome (CSN)
COP9 Signalosome Subunit 1
COP9 Signalosome Subunit 2
COP9 Signalosome Subunit 3
COP9 Signalosome Subunit 4
COP9 Signalosome Subunit 5
COP9 Signalosome Subunit 6
COP9 Signalosome Subunit 7A
COP9 Signalosome Subunit 7B
COP9 Signalosome Subunit 8
COP9 Signalsome
Constitutive Photomorphogenesis 9 Signalosome
Constitutive Photomorphogenesis 9 Signalsome
FUSCA Protein 11
G Protein Pathway Suppressor 1
Sgn3
Signalosome Subunit 3
Public MeSH Note
2018; COP9 SIGNALOSOME COMPLEX was indexed under PEPTIDE HYDROLASES and MULTIPROTEIN COMPLEXES 2006-207; under PROTEINS 1995-2005; and under PLANT PROTEINS 1995-1999; for COP9 SIGNALOSOME SUBUNIT 3 see SIGNALOSOME SUBUNIT 3 1998-2017; SIGNALOSOME SUBUNIT 3 was indexed under NUCLEAR PROTEINS and PROTEIN KINASES 1998-2017
History Note
2018 (1995); for COP9 SIGNALOSOME SUBUNIT 3 use SIGNALOSOME SUBUNIT 3 1998-2017
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/29
COP9 Signalosome Complex Preferred
COP9 Signalosome Subunit 1 Narrower
COP9 Signalosome Subunit 2 Narrower
COP9 Signalosome Subunit 3 Narrower
COP9 Signalosome Subunit 4 Narrower
COP9 Signalosome Subunit 5 Narrower
COP9 Signalosome Subunit 6 Narrower
COP9 Signalosome Subunit 7A Narrower
COP9 Signalosome Subunit 7B Narrower
COP9 Signalosome Subunit 8 Narrower
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