MeSH Browser

MeSH Heading: Apoptosomes
Tree Number(s): D05.500.099
Unique ID: D053478
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053478
Scope Note: Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
Entry Term(s): Apoptosomal Protein Complex; Apoptosome
Registry Numbers: 0
Previous Indexing: Apoptosis (1999-2006)
Public MeSH Note: 2007
History Note: 2007
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0493498
Registry Numbers: 0
Scope Note: Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
Terms: Apoptosomes Preferred Term
Term UI T663496
Date12/30/2005
LexicalTag NON
ThesaurusID NLM (2007); Apoptosomal Protein Complex
Term UI T663498
Date12/30/2005
LexicalTag NON
ThesaurusID NLM (2007); Apoptosome
Term UI T663497
Date12/30/2005
LexicalTag NON
ThesaurusID NLM (2007)

Apoptosomes MeSH Descriptor Data 2025