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Mitochondrial Permeability Transition Pore MeSH Descriptor Data 2025


MeSH Heading
Mitochondrial Permeability Transition Pore
Tree Number(s)
D05.500.437
D12.776.543.585.475.563
D12.776.575.750.563
Unique ID
D000083162
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000083162
Scope Note
A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.
Entry Term(s)
Mitochondrial Megachannel
Mitochondrial Permeability Transition Pore (mPTP)
mPTP Protein
Public MeSH Note
Mitochondrial Permeability Transition Pore was indexed under MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS 2007-2020; ION CHANNELS 2003-2006; MEMBRANE PROTEINS 1999-2002; CYCLOSPORINS 1999-2000
History Note
2021(1999)
Date Established
2021/01/01
Date of Entry
2020/07/07
Revision Date
2020/02/21
Mitochondrial Permeability Transition Pore Preferred
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