MeSH Browser

MeSH Heading: Mitochondrial Permeability Transition Pore
Tree Number(s): D05.500.437; D12.776.543.585.475.563; D12.776.575.750.563
Unique ID: D000083162
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000083162
Scope Note: A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.
Entry Term(s): Mitochondrial Megachannel; Mitochondrial Permeability Transition Pore (mPTP); mPTP Protein
Public MeSH Note: Mitochondrial Permeability Transition Pore was indexed under MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS 2007-2020; ION CHANNELS 2003-2006; MEMBRANE PROTEINS 1999-2002; CYCLOSPORINS 1999-2000
History Note: 2021(1999)
Date Established: 2021/01/01
Date of Entry: 2020/07/07
Revision Date: 2020/02/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Mitochondrial Permeability Transition Pore MeSH Descriptor Data 2025