MeSH Browser

MeSH Heading: Mitochondrial Uncoupling Proteins
Tree Number(s): D12.776.157.530.937.598; D12.776.543.585.475.688; D12.776.543.585.937.696; D12.776.575.750.688
Unique ID: D000071245
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071245
Scope Note: Mitochondrial anion carrier proteins that function as dimers and form proton channels in the INNER MITOCHONDRIAL MEMBRANE which creates proton leaks and uncouples OXIDATIVE PHOSPHORYLATION from ATP synthesis, resulting in the generation of heat instead of ATP.
Entry Term(s): Mitochondrial UCPs; Uncoupling Protein; Uncoupling Proteins
Previous Indexing: Membrane Proteins (1998-2016); Mitochondrial Proteins (1998-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Solute Carrier Proteins [D12.776.157.530.937]
        
        Amino Acid Transport System X-AG [D12.776.157.530.937.250]
        
        Amino Acid Transport System y+L [D12.776.157.530.937.313]
        
        Amino Acid Transport System y+ [D12.776.157.530.937.375]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.157.530.937.500]
        
        Equilibrative Nucleoside Transport Proteins [D12.776.157.530.937.532]
        
        Glucose Transport Proteins, Facilitative [D12.776.157.530.937.563]
        
        K Cl- Cotransporters [D12.776.157.530.937.572]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.157.530.937.580]
        
        Mitochondrial ADP, ATP Translocases [D12.776.157.530.937.594]
        
        Mitochondrial Uncoupling Proteins [D12.776.157.530.937.598]
        
        Uncoupling Protein 1 [D12.776.157.530.937.598.500]
        
        Uncoupling Protein 2 [D12.776.157.530.937.598.750]
        
        Uncoupling Protein 3 [D12.776.157.530.937.598.875]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.157.530.937.600]
        
        Organic Anion Transport Protein 1 [D12.776.157.530.937.610]
        
        Organic Cation Transport Proteins [D12.776.157.530.937.612]
        
        Peptide Transporter 1 [D12.776.157.530.937.613]
        
        Proton-Coupled Folate Transporter [D12.776.157.530.937.618]
        
        Reduced Folate Carrier Protein [D12.776.157.530.937.622]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.157.530.937.624]
        
        SLC31 Proteins [D12.776.157.530.937.640]
        
        SLC4A Proteins [D12.776.157.530.937.656]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.157.530.937.688]
        
        Sodium-Glucose Transporter 1 [D12.776.157.530.937.696]
        
        Sodium-Glucose Transporter 2 [D12.776.157.530.937.700]
        
        Sodium-Hydrogen Exchangers [D12.776.157.530.937.703]
        
        Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.157.530.937.704]
        
        Sodium-Phosphate Cotransporter Proteins, Type III [D12.776.157.530.937.719]
        
        Sodium-Potassium-Chloride Symporters [D12.776.157.530.937.750]
        
        Solute Carrier Family 44, Member 2 Protein [D12.776.157.530.937.828]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.157.530.937.905]
        
        Sulfate Transporters [D12.776.157.530.937.929]
        
        Urea Transporters [D12.776.157.530.937.941]
        
        Zinc Transporter 8 [D12.776.157.530.937.952]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Mitochondrial Membrane Transport Proteins [D12.776.543.585.475]
        
        Mitochondrial ADP, ATP Translocases [D12.776.543.585.475.500]
        
        Mitochondrial Permeability Transition Pore [D12.776.543.585.475.563]
        
        Mitochondrial Precursor Protein Import Complex Proteins [D12.776.543.585.475.594]
        
        Mitochondrial Proton-Translocating ATPases [D12.776.543.585.475.625]
        
        Mitochondrial Uncoupling Proteins [D12.776.543.585.475.688]
        
        Uncoupling Protein 1 [D12.776.543.585.475.688.500]
        
        Uncoupling Protein 2 [D12.776.543.585.475.688.750]
        
        Uncoupling Protein 3 [D12.776.543.585.475.688.875]
        
        Solute Carrier Family 44, Member 2 Protein [D12.776.543.585.475.719]
        
        Steroidogenic Acute Regulatory Protein [D12.776.543.585.475.735]
        
        Voltage-Dependent Anion Channel 1 [D12.776.543.585.475.750]
        
        Voltage-Dependent Anion Channel 2 [D12.776.543.585.475.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Solute Carrier Proteins [D12.776.543.585.937]
        
        Amino Acid Transport System X-AG [D12.776.543.585.937.250]
        
        Amino Acid Transport System y+L [D12.776.543.585.937.313]
        
        Amino Acid Transport System y+ [D12.776.543.585.937.375]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.543.585.937.500]
        
        Equilibrative Nucleoside Transport Proteins [D12.776.543.585.937.563]
        
        Glucose Transport Proteins, Facilitative [D12.776.543.585.937.625]
        
        K Cl- Cotransporters [D12.776.543.585.937.657]
        
        Mitochondrial ADP, ATP Translocases [D12.776.543.585.937.688]
        
        Mitochondrial Uncoupling Proteins [D12.776.543.585.937.696]
        
        Uncoupling Protein 1 [D12.776.543.585.937.696.500]
        
        Uncoupling Protein 2 [D12.776.543.585.937.696.750]
        
        Uncoupling Protein 3 [D12.776.543.585.937.696.875]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.543.585.937.700]
        
        Organic Cation Transport Proteins [D12.776.543.585.937.701]
        
        Peptide Transporter 1 [D12.776.543.585.937.702]
        
        Organic Anion Transport Protein 1 [D12.776.543.585.937.719]
        
        Proton-Coupled Folate Transporter [D12.776.543.585.937.735]
        
        Reduced Folate Carrier Protein [D12.776.543.585.937.743]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.543.585.937.747]
        
        SLC31 Proteins [D12.776.543.585.937.762]
        
        SLC4A Proteins [D12.776.543.585.937.776]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.543.585.937.813]
        
        Sodium-Glucose Transporter 1 [D12.776.543.585.937.821]
        
        Sodium-Glucose Transporter 2 [D12.776.543.585.937.825]
        
        Sodium-Hydrogen Exchangers [D12.776.543.585.937.828]
        
        Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.543.585.937.829]
        
        Sodium-Phosphate Cotransporter Proteins, Type III [D12.776.543.585.937.844]
        
        Sodium-Potassium-Chloride Symporters [D12.776.543.585.937.875]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.543.585.937.901]
        
        Solute Carrier Family 44, Member 2 Protein [D12.776.543.585.937.926]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.543.585.937.950]
        
        Sulfate Transporters [D12.776.543.585.937.963]
        
        Urea Transporters [D12.776.543.585.937.969]
        
        Zinc Transporter 8 [D12.776.543.585.937.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Mitochondrial Proteins [D12.776.575]
    - Mitochondrial Membrane Transport Proteins [D12.776.575.750]

Mitochondrial Uncoupling Proteins Preferred

Concept UI: M000613846
Scope Note: Mitochondrial anion carrier proteins that function as dimers and form proton channels in the INNER MITOCHONDRIAL MEMBRANE which creates proton leaks and uncouples OXIDATIVE PHOSPHORYLATION from ATP synthesis, resulting in the generation of heat instead of ATP.
Terms: Mitochondrial Uncoupling Proteins Preferred Term
Term UI T000894149
Date01/26/2016
LexicalTag NON
ThesaurusID NLM (2017); Uncoupling Proteins
Term UI T000894151
Date01/26/2016
LexicalTag NON
ThesaurusID NLM (2017); Mitochondrial UCPs
Term UI T000894153
Date01/26/2016
LexicalTag ABX
ThesaurusID NLM (2017); Uncoupling Protein
Term UI T001005726
Date01/17/2020
LexicalTag NON
ThesaurusID NLM (2021)

Mitochondrial Uncoupling Proteins MeSH Descriptor Data 2025