MeSH Browser

MeSH Heading: Zinc Transporter 8
Tree Number(s): D12.776.157.530.450.250.940; D12.776.157.530.937.952; D12.776.543.585.450.250.945; D12.776.543.585.937.975
Unique ID: D000075703
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075703
Scope Note: A zinc efflux transporter highly expressed by ISLET CELLS of the pancreas. It functions in the accumulation of zinc in intracellular vesicles and may be involved in INSULIN maturation and storage processes. Variations in the SLC30A8 gene are associated with susceptibility to DIABETES MELLITUS, TYPE 2.
Entry Term(s): Slc30A8 Protein; Solute Carrier Family 30 Member 8 Protein; ZnT-8 Protein
Previous Indexing: Cation Transport Proteins (2004-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Cation Transport Proteins [D12.776.157.530.450.250]
        
        Arsenite Transporting ATPases [D12.776.157.530.450.250.249]
        
        Calcium-Transporting ATPases [D12.776.157.530.450.250.500]
        
        Copper Transport Proteins [D12.776.157.530.450.250.578]
        
        Ferroportin [D12.776.157.530.450.250.695]
        
        Organic Cation Transport Proteins [D12.776.157.530.450.250.812]
        
        Proton Pumps [D12.776.157.530.450.250.875]
        
        Sodium Sulfate Cotransporter [D12.776.157.530.450.250.878]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.157.530.450.250.880]
        
        Solute Carrier Family 12 [D12.776.157.530.450.250.910]
        
        Zinc Transporter 8 [D12.776.157.530.450.250.940]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Solute Carrier Proteins [D12.776.157.530.937]
        
        Amino Acid Transport System X-AG [D12.776.157.530.937.250]
        
        Amino Acid Transport System y+L [D12.776.157.530.937.313]
        
        Amino Acid Transport System y+ [D12.776.157.530.937.375]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.157.530.937.500]
        
        Equilibrative Nucleoside Transport Proteins [D12.776.157.530.937.532]
        
        Glucose Transport Proteins, Facilitative [D12.776.157.530.937.563]
        
        K Cl- Cotransporters [D12.776.157.530.937.572]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.157.530.937.580]
        
        Mitochondrial ADP, ATP Translocases [D12.776.157.530.937.594]
        
        Mitochondrial Uncoupling Proteins [D12.776.157.530.937.598]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.157.530.937.600]
        
        Organic Anion Transport Protein 1 [D12.776.157.530.937.610]
        
        Organic Cation Transport Proteins [D12.776.157.530.937.612]
        
        Peptide Transporter 1 [D12.776.157.530.937.613]
        
        Proton-Coupled Folate Transporter [D12.776.157.530.937.618]
        
        Reduced Folate Carrier Protein [D12.776.157.530.937.622]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.157.530.937.624]
        
        SLC31 Proteins [D12.776.157.530.937.640]
        
        SLC4A Proteins [D12.776.157.530.937.656]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.157.530.937.688]
        
        Sodium-Glucose Transporter 1 [D12.776.157.530.937.696]
        
        Sodium-Glucose Transporter 2 [D12.776.157.530.937.700]
        
        Sodium-Hydrogen Exchangers [D12.776.157.530.937.703]
        
        Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.157.530.937.704]
        
        Sodium-Phosphate Cotransporter Proteins, Type III [D12.776.157.530.937.719]
        
        Sodium-Potassium-Chloride Symporters [D12.776.157.530.937.750]
        
        Solute Carrier Family 44, Member 2 Protein [D12.776.157.530.937.828]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.157.530.937.905]
        
        Sulfate Transporters [D12.776.157.530.937.929]
        
        Urea Transporters [D12.776.157.530.937.941]
        
        Zinc Transporter 8 [D12.776.157.530.937.952]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Cation Transport Proteins [D12.776.543.585.450.250]
        
        Arsenite Transporting ATPases [D12.776.543.585.450.250.249]
        
        Calcium-Transporting ATPases [D12.776.543.585.450.250.500]
        
        Copper Transport Proteins [D12.776.543.585.450.250.578]
        
        Organic Cation Transport Proteins [D12.776.543.585.450.250.812]
        
        Proton Pumps [D12.776.543.585.450.250.875]
        
        Sodium Sulfate Cotransporter [D12.776.543.585.450.250.883]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.543.585.450.250.890]
        
        Solute Carrier Family 12 [D12.776.543.585.450.250.918]
        
        Zinc Transporter 8 [D12.776.543.585.450.250.945]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Solute Carrier Proteins [D12.776.543.585.937]
        
        Amino Acid Transport System X-AG [D12.776.543.585.937.250]
        
        Amino Acid Transport System y+L [D12.776.543.585.937.313]
        
        Amino Acid Transport System y+ [D12.776.543.585.937.375]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.543.585.937.500]
        
        Equilibrative Nucleoside Transport Proteins [D12.776.543.585.937.563]
        
        Glucose Transport Proteins, Facilitative [D12.776.543.585.937.625]
        
        K Cl- Cotransporters [D12.776.543.585.937.657]
        
        Mitochondrial ADP, ATP Translocases [D12.776.543.585.937.688]
        
        Mitochondrial Uncoupling Proteins [D12.776.543.585.937.696]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.543.585.937.700]
        
        Organic Cation Transport Proteins [D12.776.543.585.937.701]
        
        Peptide Transporter 1 [D12.776.543.585.937.702]
        
        Organic Anion Transport Protein 1 [D12.776.543.585.937.719]
        
        Proton-Coupled Folate Transporter [D12.776.543.585.937.735]
        
        Reduced Folate Carrier Protein [D12.776.543.585.937.743]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.543.585.937.747]
        
        SLC31 Proteins [D12.776.543.585.937.762]
        
        SLC4A Proteins [D12.776.543.585.937.776]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.543.585.937.813]
        
        Sodium-Glucose Transporter 1 [D12.776.543.585.937.821]
        
        Sodium-Glucose Transporter 2 [D12.776.543.585.937.825]
        
        Sodium-Hydrogen Exchangers [D12.776.543.585.937.828]
        
        Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.543.585.937.829]
        
        Sodium-Phosphate Cotransporter Proteins, Type III [D12.776.543.585.937.844]
        
        Sodium-Potassium-Chloride Symporters [D12.776.543.585.937.875]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.543.585.937.901]
        
        Solute Carrier Family 44, Member 2 Protein [D12.776.543.585.937.926]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.543.585.937.950]
        
        Sulfate Transporters [D12.776.543.585.937.963]
        
        Urea Transporters [D12.776.543.585.937.969]
        
        Zinc Transporter 8 [D12.776.543.585.937.975]

Zinc Transporter 8 Preferred

Concept UI: M000631332
Scope Note: A zinc efflux transporter highly expressed by ISLET CELLS of the pancreas. It functions in the accumulation of zinc in intracellular vesicles and may be involved in INSULIN maturation and storage processes. Variations in the SLC30A8 gene are associated with susceptibility to DIABETES MELLITUS, TYPE 2.
Terms: Zinc Transporter 8 Preferred Term
Term UI T000923794
Date05/09/2017
LexicalTag NON
ThesaurusID NLM (2018); Slc30A8 Protein
Term UI T000923795
Date05/09/2017
LexicalTag ABX
ThesaurusID NLM (2018); ZnT-8 Protein
Term UI T000923797
Date05/09/2017
LexicalTag ABX
ThesaurusID NLM (2018); Solute Carrier Family 30 Member 8 Protein
Term UI T000923796
Date05/09/2017
LexicalTag NON
ThesaurusID NLM (2018)

Zinc Transporter 8 MeSH Descriptor Data 2025