MeSH Browser

MeSH Heading: Solute Carrier Organic Anion Transporter Family Member 1B3
Tree Number(s): D12.776.157.530.450.074.500.781.875; D12.776.157.530.937.905; D12.776.543.585.450.074.500.875.875; D12.776.543.585.937.950
Unique ID: D000074542
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074542
Scope Note: A sodium-independent organic anion transporter that functions in the uptake of various drugs and endogenous compounds including ESTRADIOL; TAUROCHOLATE; LEUKOTRIENE C4; and METHOTREXATE. It also functions in clearing BILE ACIDS and organic anions from the liver. Mutations in the SLCO1B3 gene are associated with Rotor Type HYPERBILIRUBINEMIA.
Entry Term(s): Liver-Specific Organic Anion Transporter-2; OATP1B3 Protein; OATP8 Protein; SLC21A8 Protein; SLCO1B3 Protein; Solute Carrier Family 21 Member 8 Protein
Previous Indexing: Organic Anion Transporters, Sodium-Independent (2002-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/06

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Anion Transport Proteins [D12.776.157.530.450.074]
        
        Organic Anion Transporters [D12.776.157.530.450.074.500]
        
        Organic Anion Transporters, Sodium-Independent [D12.776.157.530.450.074.500.781]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.157.530.450.074.500.781.500]
        
        Organic Anion Transport Protein 1 [D12.776.157.530.450.074.500.781.750]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.157.530.450.074.500.781.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Solute Carrier Proteins [D12.776.157.530.937]
        
        Amino Acid Transport System X-AG [D12.776.157.530.937.250]
        
        Amino Acid Transport System y+L [D12.776.157.530.937.313]
        
        Amino Acid Transport System y+ [D12.776.157.530.937.375]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.157.530.937.500]
        
        Equilibrative Nucleoside Transport Proteins [D12.776.157.530.937.532]
        
        Glucose Transport Proteins, Facilitative [D12.776.157.530.937.563]
        
        K Cl- Cotransporters [D12.776.157.530.937.572]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.157.530.937.580]
        
        Mitochondrial ADP, ATP Translocases [D12.776.157.530.937.594]
        
        Mitochondrial Uncoupling Proteins [D12.776.157.530.937.598]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.157.530.937.600]
        
        Organic Anion Transport Protein 1 [D12.776.157.530.937.610]
        
        Organic Cation Transport Proteins [D12.776.157.530.937.612]
        
        Peptide Transporter 1 [D12.776.157.530.937.613]
        
        Proton-Coupled Folate Transporter [D12.776.157.530.937.618]
        
        Reduced Folate Carrier Protein [D12.776.157.530.937.622]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.157.530.937.624]
        
        SLC31 Proteins [D12.776.157.530.937.640]
        
        SLC4A Proteins [D12.776.157.530.937.656]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.157.530.937.688]
        
        Sodium-Glucose Transporter 1 [D12.776.157.530.937.696]
        
        Sodium-Glucose Transporter 2 [D12.776.157.530.937.700]
        
        Sodium-Hydrogen Exchangers [D12.776.157.530.937.703]
        
        Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.157.530.937.704]
        
        Sodium-Phosphate Cotransporter Proteins, Type III [D12.776.157.530.937.719]
        
        Sodium-Potassium-Chloride Symporters [D12.776.157.530.937.750]
        
        Solute Carrier Family 44, Member 2 Protein [D12.776.157.530.937.828]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.157.530.937.905]
        
        Sulfate Transporters [D12.776.157.530.937.929]
        
        Urea Transporters [D12.776.157.530.937.941]
        
        Zinc Transporter 8 [D12.776.157.530.937.952]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Anion Transport Proteins [D12.776.543.585.450.074]
        
        Organic Anion Transporters [D12.776.543.585.450.074.500]
        
        Organic Anion Transporters, Sodium-Independent [D12.776.543.585.450.074.500.875]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.543.585.450.074.500.875.500]
        
        Organic Anion Transport Protein 1 [D12.776.543.585.450.074.500.875.750]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.543.585.450.074.500.875.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Solute Carrier Proteins [D12.776.543.585.937]
        
        Amino Acid Transport System X-AG [D12.776.543.585.937.250]
        
        Amino Acid Transport System y+L [D12.776.543.585.937.313]
        
        Amino Acid Transport System y+ [D12.776.543.585.937.375]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.543.585.937.500]
        
        Equilibrative Nucleoside Transport Proteins [D12.776.543.585.937.563]
        
        Glucose Transport Proteins, Facilitative [D12.776.543.585.937.625]
        
        K Cl- Cotransporters [D12.776.543.585.937.657]
        
        Mitochondrial ADP, ATP Translocases [D12.776.543.585.937.688]
        
        Mitochondrial Uncoupling Proteins [D12.776.543.585.937.696]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.543.585.937.700]
        
        Organic Cation Transport Proteins [D12.776.543.585.937.701]
        
        Peptide Transporter 1 [D12.776.543.585.937.702]
        
        Organic Anion Transport Protein 1 [D12.776.543.585.937.719]
        
        Proton-Coupled Folate Transporter [D12.776.543.585.937.735]
        
        Reduced Folate Carrier Protein [D12.776.543.585.937.743]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.543.585.937.747]
        
        SLC31 Proteins [D12.776.543.585.937.762]
        
        SLC4A Proteins [D12.776.543.585.937.776]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.543.585.937.813]
        
        Sodium-Glucose Transporter 1 [D12.776.543.585.937.821]
        
        Sodium-Glucose Transporter 2 [D12.776.543.585.937.825]
        
        Sodium-Hydrogen Exchangers [D12.776.543.585.937.828]
        
        Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.543.585.937.829]
        
        Sodium-Phosphate Cotransporter Proteins, Type III [D12.776.543.585.937.844]
        
        Sodium-Potassium-Chloride Symporters [D12.776.543.585.937.875]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.543.585.937.901]
        
        Solute Carrier Family 44, Member 2 Protein [D12.776.543.585.937.926]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.543.585.937.950]
        
        Sulfate Transporters [D12.776.543.585.937.963]
        
        Urea Transporters [D12.776.543.585.937.969]
        
        Zinc Transporter 8 [D12.776.543.585.937.975]

Solute Carrier Organic Anion Transporter Family Member 1B3 Preferred

Concept UI: M000626958
Scope Note: A sodium-independent organic anion transporter that functions in the uptake of various drugs and endogenous compounds including ESTRADIOL; TAUROCHOLATE; LEUKOTRIENE C4; and METHOTREXATE. It also functions in clearing BILE ACIDS and organic anions from the liver. Mutations in the SLCO1B3 gene are associated with Rotor Type HYPERBILIRUBINEMIA.
Terms: Solute Carrier Organic Anion Transporter Family Member 1B3 Preferred Term
Term UI T000916441
Date02/27/2017
LexicalTag NON
ThesaurusID NLM (2018); OATP8 Protein
Term UI T000916446
Date02/27/2017
LexicalTag ABX
ThesaurusID NLM (2018); SLC21A8 Protein
Term UI T000916444
Date02/27/2017
LexicalTag ABX
ThesaurusID NLM (2018); Liver-Specific Organic Anion Transporter-2
Term UI T000916443
Date02/27/2017
LexicalTag NON
ThesaurusID NLM (2018); OATP1B3 Protein
Term UI T000916447
Date02/27/2017
LexicalTag ABX
ThesaurusID NLM (2018); Solute Carrier Family 21 Member 8 Protein
Term UI T000916445
Date02/27/2017
LexicalTag NON
ThesaurusID NLM (2018); SLCO1B3 Protein
Term UI T000916442
Date02/27/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Solute Carrier Organic Anion Transporter Family Member 1B3 MeSH Descriptor Data 2025