MeSH Browser

MeSH Heading: K Cl- Cotransporters
Tree Number(s): D12.776.157.530.450.625.875.500; D12.776.157.530.937.572; D12.776.543.585.450.625.171; D12.776.543.585.937.657
Unique ID: D000096922
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000096922
Scope Note: A subclass of symporters that specifically transport POTASSIUM and CHLORIDE ions across cellular membranes. Potassium chloride cotransporters play roles in regulating cell volume and intracellular chloride concentration.
Entry Term(s): Electroneutral Potassium-Chloride Co-transporter 3; Electroneutral Potassium-Chloride Cotransporter 3; K Cl- Co-transporters; K(+), Cl(-)-Co-transporters; K(+), Cl(-)-Cotransporters; K-Cl Co-transporter; K-Cl Co-transporter 3; K-Cl Cotransporter; K-Cl Cotransporter 3; KCC2 Co-transporter; KCC2 Cotransporter; KCC3 Co-transporter; KCC3 Cotransporter; KCC4 Co-transporter; KCC4 Cotransporter; Potassium-Chloride Co-transporter 2; Potassium-Chloride Co-transporter 4; Potassium-Chloride Co-transporters; Potassium-Chloride Cotransporter 2; Potassium-Chloride Cotransporter 4; Potassium-Chloride Cotransporters; Potassium-Chloride Symporters; SLC12A5 Protein; SLC12A6 Protein; SLC12A7 Protein; Solute Carrier Family 12 Member 5; Solute Carrier Family 12 Member 6; Solute carrier family 12 member 7
Public MeSH Note: 2024; see SYMPORTERS 2002-2023, see CARRIER PROTEINS 1989-2001
History Note: 2024(1989)
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/06/14

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Symporters [D12.776.157.530.450.625]
        
        Solute Carrier Family 12 [D12.776.157.530.450.625.875]
        
        K Cl- Cotransporters [D12.776.157.530.450.625.875.500]
        
        Solute Carrier Family 12, Member 4 [D12.776.157.530.450.625.875.500.500]
        
        Sodium-Potassium-Chloride Symporters [D12.776.157.530.450.625.875.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Solute Carrier Proteins [D12.776.157.530.937]
        
        Amino Acid Transport System X-AG [D12.776.157.530.937.250]
        
        Amino Acid Transport System y+L [D12.776.157.530.937.313]
        
        Amino Acid Transport System y+ [D12.776.157.530.937.375]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.157.530.937.500]
        
        Equilibrative Nucleoside Transport Proteins [D12.776.157.530.937.532]
        
        Glucose Transport Proteins, Facilitative [D12.776.157.530.937.563]
        
        K Cl- Cotransporters [D12.776.157.530.937.572]
        
        Solute Carrier Family 12, Member 4 [D12.776.157.530.937.572.500]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.157.530.937.580]
        
        Mitochondrial ADP, ATP Translocases [D12.776.157.530.937.594]
        
        Mitochondrial Uncoupling Proteins [D12.776.157.530.937.598]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.157.530.937.600]
        
        Organic Anion Transport Protein 1 [D12.776.157.530.937.610]
        
        Organic Cation Transport Proteins [D12.776.157.530.937.612]
        
        Peptide Transporter 1 [D12.776.157.530.937.613]
        
        Proton-Coupled Folate Transporter [D12.776.157.530.937.618]
        
        Reduced Folate Carrier Protein [D12.776.157.530.937.622]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.157.530.937.624]
        
        SLC31 Proteins [D12.776.157.530.937.640]
        
        SLC4A Proteins [D12.776.157.530.937.656]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.157.530.937.688]
        
        Sodium-Glucose Transporter 1 [D12.776.157.530.937.696]
        
        Sodium-Glucose Transporter 2 [D12.776.157.530.937.700]
        
        Sodium-Hydrogen Exchangers [D12.776.157.530.937.703]
        
        Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.157.530.937.704]
        
        Sodium-Phosphate Cotransporter Proteins, Type III [D12.776.157.530.937.719]
        
        Sodium-Potassium-Chloride Symporters [D12.776.157.530.937.750]
        
        Solute Carrier Family 44, Member 2 Protein [D12.776.157.530.937.828]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.157.530.937.905]
        
        Sulfate Transporters [D12.776.157.530.937.929]
        
        Urea Transporters [D12.776.157.530.937.941]
        
        Zinc Transporter 8 [D12.776.157.530.937.952]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Symporters [D12.776.543.585.450.625]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.543.585.450.625.124]
        
        GABA Plasma Membrane Transport Proteins [D12.776.543.585.450.625.139]
        
        Glutamate Plasma Membrane Transport Proteins [D12.776.543.585.450.625.147]
        
        Glycine Plasma Membrane Transport Proteins [D12.776.543.585.450.625.155]
        
        K Cl- Cotransporters [D12.776.543.585.450.625.171]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.543.585.450.625.186]
        
        Peptide Transporter 1 [D12.776.543.585.450.625.202]
        
        Proton-Coupled Folate Transporter [D12.776.543.585.450.625.217]
        
        Proton-Phosphate Symporters [D12.776.543.585.450.625.249]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.543.585.450.625.374]
        
        Sodium Sulfate Cotransporter [D12.776.543.585.450.625.437]
        
        Sodium-Bicarbonate Symporters [D12.776.543.585.450.625.500]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.543.585.450.625.531]
        
        Sodium-Glucose Transport Proteins [D12.776.543.585.450.625.562]
        
        Sodium-Phosphate Cotransporter Proteins [D12.776.543.585.450.625.625]
        
        Sodium-Potassium-Chloride Symporters [D12.776.543.585.450.625.750]
        
        Solute Carrier Family 12 [D12.776.543.585.450.625.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Solute Carrier Proteins [D12.776.543.585.937]
        
        Amino Acid Transport System X-AG [D12.776.543.585.937.250]
        
        Amino Acid Transport System y+L [D12.776.543.585.937.313]
        
        Amino Acid Transport System y+ [D12.776.543.585.937.375]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.543.585.937.500]
        
        Equilibrative Nucleoside Transport Proteins [D12.776.543.585.937.563]
        
        Glucose Transport Proteins, Facilitative [D12.776.543.585.937.625]
        
        K Cl- Cotransporters [D12.776.543.585.937.657]
        
        Mitochondrial ADP, ATP Translocases [D12.776.543.585.937.688]
        
        Mitochondrial Uncoupling Proteins [D12.776.543.585.937.696]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.543.585.937.700]
        
        Organic Cation Transport Proteins [D12.776.543.585.937.701]
        
        Peptide Transporter 1 [D12.776.543.585.937.702]
        
        Organic Anion Transport Protein 1 [D12.776.543.585.937.719]
        
        Proton-Coupled Folate Transporter [D12.776.543.585.937.735]
        
        Reduced Folate Carrier Protein [D12.776.543.585.937.743]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.543.585.937.747]
        
        SLC31 Proteins [D12.776.543.585.937.762]
        
        SLC4A Proteins [D12.776.543.585.937.776]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.543.585.937.813]
        
        Sodium-Glucose Transporter 1 [D12.776.543.585.937.821]
        
        Sodium-Glucose Transporter 2 [D12.776.543.585.937.825]
        
        Sodium-Hydrogen Exchangers [D12.776.543.585.937.828]
        
        Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.543.585.937.829]
        
        Sodium-Phosphate Cotransporter Proteins, Type III [D12.776.543.585.937.844]
        
        Sodium-Potassium-Chloride Symporters [D12.776.543.585.937.875]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.543.585.937.901]
        
        Solute Carrier Family 44, Member 2 Protein [D12.776.543.585.937.926]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.543.585.937.950]
        
        Sulfate Transporters [D12.776.543.585.937.963]
        
        Urea Transporters [D12.776.543.585.937.969]
        
        Zinc Transporter 8 [D12.776.543.585.937.975]

K Cl- Cotransporters Preferred

Concept UI: M000762765
Scope Note: A subclass of symporters that specifically transport POTASSIUM and CHLORIDE ions across cellular membranes. Potassium chloride cotransporters play roles in regulating cell volume and intracellular chloride concentration.
Terms: K Cl- Cotransporters Preferred Term
Term UI T001132965
Date02/16/2023
LexicalTag NON
ThesaurusID NLM (2024); Potassium-Chloride Cotransporters
Term UI T001135684
Date03/30/2023
LexicalTag NON
ThesaurusID NLM (2024); K(+), Cl(-)-Co-transporters
Term UI T001136270
Date04/14/2023
LexicalTag NON
ThesaurusID NLM (2024); K-Cl Co-transporter
Term UI T001136271
Date04/14/2023
LexicalTag NON
ThesaurusID NLM (2024); Potassium-Chloride Co-transporters
Term UI T001136272
Date04/14/2023
LexicalTag NON
ThesaurusID NLM (2024); K Cl- Co-transporters
Term UI T001136269
Date04/14/2023
LexicalTag NON
ThesaurusID NLM (2024); Potassium-Chloride Symporters
Term UI T001135687
Date03/30/2023
LexicalTag NON
ThesaurusID NLM (2024); K(+), Cl(-)-Cotransporters
Term UI T001135686
Date03/30/2023
LexicalTag NON
ThesaurusID NLM (2024); K-Cl Cotransporter
Term UI T001135685
Date03/30/2023
LexicalTag NON
ThesaurusID NLM (2024)

Solute Carrier Family 12 Member 5 Narrower

Concept UI: M0163465
Scope Note: Neuronal potassium chloride cotransporter.
Terms: Solute Carrier Family 12 Member 5 Preferred Term
Term UI T001135682
Date03/30/2023
LexicalTag NON
ThesaurusID NLM (2024); KCC2 Cotransporter
Term UI T001135679
Date03/30/2023
LexicalTag ABX
ThesaurusID NLM (2024); Potassium-Chloride Cotransporter 2
Term UI T001135680
Date03/30/2023
LexicalTag NON
ThesaurusID NLM (2024); SLC12A5 Protein
Term UI T001135681
Date03/30/2023
LexicalTag ABX
ThesaurusID NLM (2024); Potassium-Chloride Co-transporter 2
Term UI T001136278
Date04/14/2023
LexicalTag NON
ThesaurusID NLM (2024); KCC2 Co-transporter
Term UI T001136279
Date04/14/2023
LexicalTag ABX
ThesaurusID NLM (2024)

Solute Carrier Family 12 Member 6 Narrower

Solute carrier family 12 member 7 Narrower

Concept UI: M000764011
Terms: Solute carrier family 12 member 7 Preferred Term
Term UI T001135695
Date03/30/2023
LexicalTag NON
ThesaurusID NLM (2024); SLC12A7 Protein
Term UI T001135696
Date03/30/2023
LexicalTag ABX
ThesaurusID NLM (2024); KCC4 Co-transporter
Term UI T001136273
Date04/14/2023
LexicalTag ABX
ThesaurusID NLM (2024); Potassium-Chloride Co-transporter 4
Term UI T001136274
Date04/14/2023
LexicalTag NON
ThesaurusID NLM (2024); Potassium-Chloride Cotransporter 4
Term UI T001135697
Date03/30/2023
LexicalTag NON
ThesaurusID NLM (2024); KCC4 Cotransporter
Term UI T001135699
Date03/30/2023
LexicalTag ABX
ThesaurusID NLM (2024)

K Cl- Cotransporters MeSH Descriptor Data 2025