MeSH Browser

MeSH Heading: Sodium-Bicarbonate Symporters
Tree Number(s): D12.776.157.530.450.437.500; D12.776.157.530.450.625.500; D12.776.157.530.937.656.500; D12.776.543.550.779.500; D12.776.543.585.450.437.500; D12.776.543.585.450.625.500; D12.776.543.585.937.776.500
Unique ID: D027982
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D027982
Scope Note: Proteins that cotransport sodium ions and bicarbonate ions across cellular membranes.
Entry Term(s): Electrogenic Sodium Bicarbonate Cotransporter 1; Electrogenic Sodium Bicarbonate Cotransporter 4; Electroneutral Na(+)-Driven Cl-HCO3 Exchanger; Electroneutral Sodium Bicarbonate Exchanger 1; NBC1 Protein; NBC3 Protein; NBC4 Protein; NBCE1 Protein; NBCe2 Protein; NBCn2 Protein; NCBE Protein; Na-HCO3 Symport; SLC4A10 Protein; SLC4A4 Protein; SLC4A5 Protein; SLC4A7 Protein; SLC4A8 Protein; Sodium Bicarbonate Cotransporter 2; Sodium Bicarbonate Cotransporter 3; Sodium Bicarbonate Symport; Sodium-Bicarbonate Cotransporter; Sodium-Coupled Bicarbonate Transporters; Sodium-driven chloride bicarbonate exchanger; Solute Carrier Family 4 Member 10; Solute Carrier Family 4 Member 4; Solute Carrier Family 4 Member 5; Solute Carrier Family 4 Member 7; Solute Carrier Family 4 Member 8; Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 10; Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4; Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 5; Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 7; Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 8; k-NBC3 Protein
Previous Indexing: Carrier Proteins (1986-2001)
Public MeSH Note: 2002; SODIUM BICARBONATE SYMPORT (now SODIUM-BICARBONATE SYMPORTERS) was indexed under CARRIER PROTEINS 1986-2001
History Note: 2002; use SODIUM-BICARBONATE SYMPORTERS (NM) 1986-2001
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2019/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        SLC4A Proteins [D12.776.157.530.450.437]
        
        Chloride-Bicarbonate Antiporters [D12.776.157.530.450.437.249]
        
        Sodium-Bicarbonate Symporters [D12.776.157.530.450.437.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Symporters [D12.776.157.530.450.625]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.157.530.450.625.124]
        
        GABA Plasma Membrane Transport Proteins [D12.776.157.530.450.625.139]
        
        Glutamate Plasma Membrane Transport Proteins [D12.776.157.530.450.625.147]
        
        Glycine Plasma Membrane Transport Proteins [D12.776.157.530.450.625.155]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.157.530.450.625.186]
        
        Peptide Transporter 1 [D12.776.157.530.450.625.202]
        
        Proton-Coupled Folate Transporter [D12.776.157.530.450.625.217]
        
        Proton-Phosphate Symporters [D12.776.157.530.450.625.249]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.157.530.450.625.311]
        
        Sodium Chloride Symporters [D12.776.157.530.450.625.374]
        
        Sodium Sulfate Cotransporter [D12.776.157.530.450.625.390]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.157.530.450.625.405]
        
        Sodium-Glucose Transport Proteins [D12.776.157.530.450.625.437]
        
        Sodium-Bicarbonate Symporters [D12.776.157.530.450.625.500]
        
        Sodium-Phosphate Cotransporter Proteins [D12.776.157.530.450.625.625]
        
        Solute Carrier Family 12 [D12.776.157.530.450.625.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Solute Carrier Proteins [D12.776.157.530.937]
        
        SLC4A Proteins [D12.776.157.530.937.656]
        
        Chloride-Bicarbonate Antiporters [D12.776.157.530.937.656.249]
        
        Sodium-Bicarbonate Symporters [D12.776.157.530.937.656.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - SLC4A Proteins [D12.776.543.550.779]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.550.779.249]
        
        Sodium-Bicarbonate Symporters [D12.776.543.550.779.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        SLC4A Proteins [D12.776.543.585.450.437]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.585.450.437.249]
        
        Sodium-Bicarbonate Symporters [D12.776.543.585.450.437.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Symporters [D12.776.543.585.450.625]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.543.585.450.625.124]
        
        GABA Plasma Membrane Transport Proteins [D12.776.543.585.450.625.139]
        
        Glutamate Plasma Membrane Transport Proteins [D12.776.543.585.450.625.147]
        
        Glycine Plasma Membrane Transport Proteins [D12.776.543.585.450.625.155]
        
        K Cl- Cotransporters [D12.776.543.585.450.625.171]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.543.585.450.625.186]
        
        Peptide Transporter 1 [D12.776.543.585.450.625.202]
        
        Proton-Coupled Folate Transporter [D12.776.543.585.450.625.217]
        
        Proton-Phosphate Symporters [D12.776.543.585.450.625.249]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.543.585.450.625.374]
        
        Sodium Sulfate Cotransporter [D12.776.543.585.450.625.437]
        
        Sodium-Bicarbonate Symporters [D12.776.543.585.450.625.500]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.543.585.450.625.531]
        
        Sodium-Glucose Transport Proteins [D12.776.543.585.450.625.562]
        
        Sodium-Phosphate Cotransporter Proteins [D12.776.543.585.450.625.625]
        
        Sodium-Potassium-Chloride Symporters [D12.776.543.585.450.625.750]
        
        Solute Carrier Family 12 [D12.776.543.585.450.625.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Solute Carrier Proteins [D12.776.543.585.937]
        
        SLC4A Proteins [D12.776.543.585.937.776]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.585.937.776.249]
        
        Sodium-Bicarbonate Symporters [D12.776.543.585.937.776.500]

Sodium-Bicarbonate Symporters Preferred

Concept UI: M0140377
Scope Note: Proteins that cotransport sodium ions and bicarbonate ions across cellular membranes.
Terms: Sodium-Bicarbonate Symporters Preferred Term
Term UI T439781
Date03/19/2001
LexicalTag NON
ThesaurusID NLM (2002); Sodium-Coupled Bicarbonate Transporters
Term UI T839968
Date04/05/2013
LexicalTag NON
ThesaurusID NLM (2014); Na-HCO3 Symport
Term UI T170376
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); Sodium-Bicarbonate Cotransporter
Term UI T170381
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Sodium Bicarbonate Symport
Term UI T170382
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002)

SLC4A4 Protein Narrower

SLC4A5 Protein Narrower

Concept UI: M0582702
Scope Note: electrogenic sodium-coupled bicarbonate transporters (SLC4A4 and 5); electroneutral sodium-coupled bicarbonate transporters (SLC4A7, 8 and 10)
Terms: SLC4A5 Protein Preferred Term
Term UI T839812
Date04/04/2013
LexicalTag ABX
ThesaurusID NLM (2014); Solute Carrier Family 4 Member 5
Term UI T839872
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 5
Term UI T839837
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); NBC4 Protein
Term UI T839838
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Electrogenic Sodium Bicarbonate Cotransporter 4
Term UI T839839
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); NBCe2 Protein
Term UI T839841
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014)

SLC4A7 Protein Narrower

SLC4A8 Protein Narrower

SLC4A10 Protein Narrower

Sodium-Bicarbonate Symporters MeSH Descriptor Data 2025