MeSH Browser

MeSH Heading: Chloride-Bicarbonate Antiporters
Tree Number(s): D12.776.157.530.450.162.193; D12.776.157.530.450.437.249; D12.776.157.530.937.656.249; D12.776.543.550.190.276; D12.776.543.550.779.249; D12.776.543.585.450.162.193; D12.776.543.585.450.437.249; D12.776.543.585.937.776.249
Unique ID: D027963
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D027963
Scope Note: Electroneutral chloride bicarbonate exchangers that allow the exchange of BICARBONATE IONS exchange for CHLORIDE IONS across the cellular membrane. The action of specific antiporters in this class serve important functions such as allowing the efficient exchange of bicarbonate across red blood cell membranes as they passage through capillaries and the reabsorption of bicarbonate ions by the kidney.
Entry Term(s): AE Proteins; AE2 Anion Exchanger; AE2 Chloride-Bicarbonate Exchanger; AE3 Anion Exchanger; AE4 Anion Exchanger; Anion Exchange Protein 2; Anion Exchange Protein 3; Anion Exchange Protein 4; Anion Exchanger 2; Anion Exchanger 3; Anion Exchanger 4; Bicarbonate-Chloride Antiport; Cardiac Brain Band 3-Like Protein; Chloride-Bicarbonate Exchanger; Chloride-Bicarbonate Exchangers; Cl(-)-HCO3(-)-Exchanger; Cl- HCO3- Exchanger; Cl- HCO3- Exchangers; Neuronal Band 3-Like Protein; Non-Erythroid Band 3-Like Protein; SLC4A2 Protein; SLC4A3 Protein; SLC4A9 Protein; Sodium Bicarbonate Cotransporter 5; Solute Carrier Family 4 Member 2; Solute Carrier Family 4 Member 3; Solute Carrier Family 4 Member 9; Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 9
Previous Indexing: Antiporters (1994-2001); Carrier Proteins (1984-1993)
Public MeSH Note: 2002; CHLORIDE-BICARBONATE EXCHANGER (now CHLORIDE-BICARBONATE ANTIPORTERS) was indexed under ANTIPORTERS 1994-2001 & under CARRIER PROTEINS 1984-1993
History Note: 2002; use CHLORIDE-BICARBONATE ANTIPORTERS (NM) 1984-2001
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2019/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Antiporters [D12.776.157.530.450.162]
        
        Chloride-Bicarbonate Antiporters [D12.776.157.530.450.162.193]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.157.530.450.162.193.500]
        
        Potassium-Hydrogen Antiporters [D12.776.157.530.450.162.276]
        
        Reduced Folate Carrier Protein [D12.776.157.530.450.162.359]
        
        Sodium-Calcium Exchanger [D12.776.157.530.450.162.442]
        
        Sodium-Hydrogen Exchangers [D12.776.157.530.450.162.775]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.157.530.450.162.780]
        
        Vesicular Neurotransmitter Transport Proteins [D12.776.157.530.450.162.887]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        SLC4A Proteins [D12.776.157.530.450.437]
        
        Chloride-Bicarbonate Antiporters [D12.776.157.530.450.437.249]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.157.530.450.437.249.500]
        
        Sodium-Bicarbonate Symporters [D12.776.157.530.450.437.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Solute Carrier Proteins [D12.776.157.530.937]
        
        SLC4A Proteins [D12.776.157.530.937.656]
        
        Chloride-Bicarbonate Antiporters [D12.776.157.530.937.656.249]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.157.530.937.656.249.500]
        
        Sodium-Bicarbonate Symporters [D12.776.157.530.937.656.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Antiporters [D12.776.543.550.190]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.550.190.276]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.543.550.190.276.500]
        
        Potassium-Hydrogen Antiporters [D12.776.543.550.190.442]
        
        Reduced Folate Carrier Protein [D12.776.543.550.190.608]
        
        Sodium-Hydrogen Exchangers [D12.776.543.550.190.775]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - SLC4A Proteins [D12.776.543.550.779]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.550.779.249]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.543.550.779.249.500]
        
        Sodium-Bicarbonate Symporters [D12.776.543.550.779.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Antiporters [D12.776.543.585.450.162]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.585.450.162.193]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.543.585.450.162.193.500]
        
        Mitochondrial ADP, ATP Translocases [D12.776.543.585.450.162.225]
        
        Organic Anion Transport Protein 1 [D12.776.543.585.450.162.234]
        
        Potassium-Hydrogen Antiporters [D12.776.543.585.450.162.276]
        
        Reduced Folate Carrier Protein [D12.776.543.585.450.162.359]
        
        Sodium-Calcium Exchanger [D12.776.543.585.450.162.442]
        
        Sodium-Hydrogen Exchangers [D12.776.543.585.450.162.775]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.543.585.450.162.800]
        
        Vesicular Neurotransmitter Transport Proteins [D12.776.543.585.450.162.887]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        SLC4A Proteins [D12.776.543.585.450.437]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.585.450.437.249]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.543.585.450.437.249.500]
        
        Sodium-Bicarbonate Symporters [D12.776.543.585.450.437.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Solute Carrier Proteins [D12.776.543.585.937]
        
        SLC4A Proteins [D12.776.543.585.937.776]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.585.937.776.249]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.543.585.937.776.249.500]
        
        Sodium-Bicarbonate Symporters [D12.776.543.585.937.776.500]

Chloride-Bicarbonate Antiporters Preferred

Concept UI: M0124849
Scope Note: Electroneutral chloride bicarbonate exchangers that allow the exchange of BICARBONATE IONS exchange for CHLORIDE IONS across the cellular membrane. The action of specific antiporters in this class serve important functions such as allowing the efficient exchange of bicarbonate across red blood cell membranes as they passage through capillaries and the reabsorption of bicarbonate ions by the kidney.
Terms: Chloride-Bicarbonate Antiporters Preferred Term
Term UI T154853
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Cl- HCO3- Exchangers
Term UI T839974
Date04/05/2013
LexicalTag NON
ThesaurusID NLM (2014); Cl(-)-HCO3(-)-Exchanger
Term UI T154849
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); Cl- HCO3- Exchanger
Term UI T154851
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); Bicarbonate-Chloride Antiport
Term UI T154852
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Chloride-Bicarbonate Exchanger
Term UI T154854
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); AE Proteins
Term UI T839973
Date04/05/2013
LexicalTag ABX
ThesaurusID NLM (2014); Chloride-Bicarbonate Exchangers
Term UI T439747
Date03/19/2001
LexicalTag NON
ThesaurusID NLM (2002)

SLC4A2 Protein Narrower

Concept UI: M0178787
Terms: SLC4A2 Protein Preferred Term
Term UI T839808
Date04/04/2013
LexicalTag ABX
ThesaurusID NLM (2014); Non-Erythroid Band 3-Like Protein
Term UI T839824
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Solute Carrier Family 4 Member 2
Term UI T839825
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); AE2 Chloride-Bicarbonate Exchanger
Term UI T839823
Date04/04/2013
LexicalTag ABX
ThesaurusID NLM (2014); AE2 Anion Exchanger
Term UI T839809
Date04/04/2013
LexicalTag ABX
ThesaurusID NLM (2014); Anion Exchange Protein 2
Term UI T839820
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Anion Exchanger 2
Term UI T839821
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014)

SLC4A3 Protein Narrower

Concept UI: M0582700
Terms: SLC4A3 Protein Preferred Term
Term UI T839810
Date04/04/2013
LexicalTag ABX
ThesaurusID NLM (2014); Anion Exchanger 3
Term UI T839827
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); AE3 Anion Exchanger
Term UI T839828
Date04/04/2013
LexicalTag ABX
ThesaurusID NLM (2014); Anion Exchange Protein 3
Term UI T839826
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Neuronal Band 3-Like Protein
Term UI T839830
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Solute Carrier Family 4 Member 3
Term UI T839831
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Cardiac Brain Band 3-Like Protein
Term UI T839829
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014)

SLC4A9 Protein Narrower

Chloride-Bicarbonate Antiporters MeSH Descriptor Data 2025