MeSH Browser

MeSH Heading: Anion Exchange Protein 1, Erythrocyte
Tree Number(s): D12.776.157.530.450.162.193.500; D12.776.157.530.450.437.249.500; D12.776.157.530.937.656.249.500; D12.776.543.550.190.276.500; D12.776.543.550.779.249.500; D12.776.543.585.450.162.193.500; D12.776.543.585.450.437.249.500; D12.776.543.585.937.776.249.500
Unique ID: D001457
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D001457
Scope Note: A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.
Entry Term(s): AE1 Anion Exchanger; AE1 Chloride-Bicarbonate Exchanger; AE1 Cl- HCO3- Exchanger; AE1 Gene Product; Anion Exchanger 1; Anion Transport Protein, Erythrocyte; Antigens, CD233; Band 3 Anion Transport Protein; Band 3 Protein; Band III Protein; CD233 Antigen; CD233 Antigens; Capnophorin; EPB3 Protein; Erythrocyte Anion Exchanger; Erythrocyte Anion Transport Protein; Erythrocyte Membrane Anion Transport Protein; Erythrocyte Membrane Band 3 Protein; Erythrocyte Membrane Protein Band 3, Diego Blood Group; Protein Band 3; SLC4A1 Protein; Solute Carrier Family 4 Member 1; Solute Carrier Family 4, Anion Exchanger, Member 1
Previous Indexing: Blood Proteins (1966-1983); Membrane Proteins (1977-1983)
See Also: Spherocytosis, Hereditary
Public MeSH Note: 2002; see BAND 3 PROTEIN 1984-2000; AE1 ANION EXCHANGER, AE1 CHLORIDE-BICARBONATE EXCHANGER, AE1 Cl- HCO3- EXCHANGER & AE1 GENE PRODUCT were indexed under ANTIPORTERS 1998-2001
History Note: 2002(1984); for AE1 ANION EXCHANGER, AE1 CHLORIDE-BICARBONATE EXCHANGER, AE1 Cl- HCO3- EXCHANGER & AE1 GENE PRODUCT use CHLORIDE-BICARBONATE ANTIPORTERS (NM) 1998-2001
Date Established: 1984/01/01
Date of Entry: 1983/05/31
Revision Date: 2019/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Antiporters [D12.776.157.530.450.162]
        
        Chloride-Bicarbonate Antiporters [D12.776.157.530.450.162.193]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.157.530.450.162.193.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        SLC4A Proteins [D12.776.157.530.450.437]
        
        Chloride-Bicarbonate Antiporters [D12.776.157.530.450.437.249]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.157.530.450.437.249.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Solute Carrier Proteins [D12.776.157.530.937]
        
        SLC4A Proteins [D12.776.157.530.937.656]
        
        Chloride-Bicarbonate Antiporters [D12.776.157.530.937.656.249]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.157.530.937.656.249.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Antiporters [D12.776.543.550.190]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.550.190.276]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.543.550.190.276.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - SLC4A Proteins [D12.776.543.550.779]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.550.779.249]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.543.550.779.249.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Antiporters [D12.776.543.585.450.162]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.585.450.162.193]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.543.585.450.162.193.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        SLC4A Proteins [D12.776.543.585.450.437]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.585.450.437.249]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.543.585.450.437.249.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Solute Carrier Proteins [D12.776.543.585.937]
        
        SLC4A Proteins [D12.776.543.585.937.776]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.585.937.776.249]
        
        Anion Exchange Protein 1, Erythrocyte [D12.776.543.585.937.776.249.500]

Anion Exchange Protein 1, Erythrocyte Preferred

Concept UI: M0002166
Scope Note: A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.
Terms: Anion Exchange Protein 1, Erythrocyte Preferred Term
Term UI T439748
Date03/19/2001
LexicalTag NON
ThesaurusID NLM (2002); Band 3 Protein
Term UI T004234
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1984); Band III Protein
Term UI T004235
Date05/31/1983
LexicalTag NON
ThesaurusID UNK (19XX); Capnophorin
Term UI T004236
Date10/07/1986
LexicalTag NON
ThesaurusID UNK (19XX); Erythrocyte Anion Transport Protein
Term UI T004237
Date04/03/1992
LexicalTag NON
ThesaurusID NLM (1993); Anion Transport Protein, Erythrocyte
Term UI T004238
Date04/03/1992
LexicalTag NON
ThesaurusID NLM (1993); Erythrocyte Membrane Band 3 Protein
Term UI T004239
Date05/31/1983
LexicalTag NON
ThesaurusID UNK (19XX); Erythrocyte Anion Exchanger
Term UI T004240
Date04/03/1992
LexicalTag NON
ThesaurusID NLM (1993); Erythrocyte Membrane Anion Transport Protein
Term UI T004241
Date04/08/1992
LexicalTag NON
ThesaurusID NLM (1993); AE1 Cl- HCO3- Exchanger
Term UI T154845
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); AE1 Anion Exchanger
Term UI T154846
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); AE1 Chloride-Bicarbonate Exchanger
Term UI T154847
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); AE1 Gene Product
Term UI T154848
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); SLC4A1 Protein
Term UI T839729
Date04/03/2013
LexicalTag ABX
ThesaurusID NLM (2014); Band 3 Anion Transport Protein
Term UI T839730
Date04/03/2013
LexicalTag NON
ThesaurusID NLM (2014); Solute Carrier Family 4 Member 1
Term UI T839731
Date04/03/2013
LexicalTag NON
ThesaurusID NLM (2014); EPB3 Protein
Term UI T839732
Date04/03/2013
LexicalTag ABX
ThesaurusID NLM (2014); Anion Exchanger 1
Term UI T839733
Date04/03/2013
LexicalTag NON
ThesaurusID NLM (2014); CD233 Antigen
Term UI T839734
Date04/03/2013
LexicalTag ACX
ThesaurusID NLM (2014); CD233 Antigens
Term UI T839735
Date04/03/2013
LexicalTag ACX
ThesaurusID NLM (2014); Antigens, CD233
Term UI T839736
Date04/03/2013
LexicalTag ABX
ThesaurusID NLM (2014); Solute Carrier Family 4, Anion Exchanger, Member 1
Term UI T839818
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Protein Band 3
Term UI T004233
Date05/31/1983
LexicalTag NON
ThesaurusID UNK (19XX); Erythrocyte Membrane Protein Band 3, Diego Blood Group
Term UI T839819
Date04/04/2013
LexicalTag NON
ThesaurusID NLM (2014)

Anion Exchange Protein 1, Erythrocyte MeSH Descriptor Data 2025