MeSH Browser

MeSH Heading: Sodium-Potassium-Exchanging ATPase
Tree Number(s): D08.811.277.040.025.314.750; D12.776.157.530.450.162.780; D12.776.157.530.450.250.880; D12.776.157.530.813.750; D12.776.543.585.450.162.800; D12.776.543.585.450.250.890; D12.776.543.585.813.750
Unique ID: D000254
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000254
Scope Note: An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
Entry Term(s): ATPase, Sodium, Potassium; Adenosine Triphosphatase, Sodium, Potassium; Adenosinetriphosphatase, Sodium, Potassium; Na(+) K(+)-Transporting ATPase; Na(+)-K(+)-Exchanging ATPase; Na(+)-K(+)-Transporting ATPase; Potassium Pump; Sodium Pump; Sodium, Potassium ATPase; Sodium, Potassium Adenosine Triphosphatase; Sodium, Potassium Adenosinetriphosphatase; Sodium-Potassium Pump
CAS Type 1 Name: ATP phosphohydrolase (Na(+)-K(+)-transporting)
NLM Classification #: QU 136
Previous Indexing: Adenosine Triphosphatase (1966-1978); Potassium (1966-1978); Sodium (1966-1978)
Public MeSH Note: 2008; see NA(+)-K(+)-EXCHANGING ATPASE 1994-2007, see NA(+) K(+)-TRANSPORTING ATPASE 1993; see SODIUM-POTASSIUM PUMP 1992-93; see ADENOSINE TRIPHOSPHATASE, SODIUM, POTASSIUM 1979-1992
History Note: 2008(1978)
Date Established: 1979/01/01
Date of Entry: 1978/03/06
Revision Date: 2019/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Acid Anhydride Hydrolases [D08.811.277.040]
      - Adenosine Triphosphatases [D08.811.277.040.025]
        
        P-type ATPases [D08.811.277.040.025.314]
        
        Calcium-Transporting ATPases [D08.811.277.040.025.314.250]
        
        Copper-Transporting ATPases [D08.811.277.040.025.314.500]
        
        H(+)-K(+)-Exchanging ATPase [D08.811.277.040.025.314.625]
        
        Sodium-Potassium-Exchanging ATPase [D08.811.277.040.025.314.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Antiporters [D12.776.157.530.450.162]
        
        Chloride-Bicarbonate Antiporters [D12.776.157.530.450.162.193]
        
        Potassium-Hydrogen Antiporters [D12.776.157.530.450.162.276]
        
        Reduced Folate Carrier Protein [D12.776.157.530.450.162.359]
        
        Sodium-Calcium Exchanger [D12.776.157.530.450.162.442]
        
        Sodium-Hydrogen Exchangers [D12.776.157.530.450.162.775]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.157.530.450.162.780]
        
        Vesicular Neurotransmitter Transport Proteins [D12.776.157.530.450.162.887]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Cation Transport Proteins [D12.776.157.530.450.250]
        
        Arsenite Transporting ATPases [D12.776.157.530.450.250.249]
        
        Calcium-Transporting ATPases [D12.776.157.530.450.250.500]
        
        Copper Transport Proteins [D12.776.157.530.450.250.578]
        
        Ferroportin [D12.776.157.530.450.250.695]
        
        Organic Cation Transport Proteins [D12.776.157.530.450.250.812]
        
        Proton Pumps [D12.776.157.530.450.250.875]
        
        Sodium Sulfate Cotransporter [D12.776.157.530.450.250.878]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.157.530.450.250.880]
        
        Solute Carrier Family 12 [D12.776.157.530.450.250.910]
        
        Zinc Transporter 8 [D12.776.157.530.450.250.940]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - P-type ATPases [D12.776.157.530.813]
        
        Calcium-Transporting ATPases [D12.776.157.530.813.250]
        
        Copper-Transporting ATPases [D12.776.157.530.813.500]
        
        H(+)-K(+)-Exchanging ATPase [D12.776.157.530.813.625]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.157.530.813.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Antiporters [D12.776.543.585.450.162]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.585.450.162.193]
        
        Mitochondrial ADP, ATP Translocases [D12.776.543.585.450.162.225]
        
        Organic Anion Transport Protein 1 [D12.776.543.585.450.162.234]
        
        Potassium-Hydrogen Antiporters [D12.776.543.585.450.162.276]
        
        Reduced Folate Carrier Protein [D12.776.543.585.450.162.359]
        
        Sodium-Calcium Exchanger [D12.776.543.585.450.162.442]
        
        Sodium-Hydrogen Exchangers [D12.776.543.585.450.162.775]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.543.585.450.162.800]
        
        Vesicular Neurotransmitter Transport Proteins [D12.776.543.585.450.162.887]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Cation Transport Proteins [D12.776.543.585.450.250]
        
        Arsenite Transporting ATPases [D12.776.543.585.450.250.249]
        
        Calcium-Transporting ATPases [D12.776.543.585.450.250.500]
        
        Copper Transport Proteins [D12.776.543.585.450.250.578]
        
        Organic Cation Transport Proteins [D12.776.543.585.450.250.812]
        
        Proton Pumps [D12.776.543.585.450.250.875]
        
        Sodium Sulfate Cotransporter [D12.776.543.585.450.250.883]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.543.585.450.250.890]
        
        Solute Carrier Family 12 [D12.776.543.585.450.250.918]
        
        Zinc Transporter 8 [D12.776.543.585.450.250.945]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - P-type ATPases [D12.776.543.585.813]
        
        Calcium-Transporting ATPases [D12.776.543.585.813.250]
        
        Copper-Transporting ATPases [D12.776.543.585.813.500]
        
        H(+)-K(+)-Exchanging ATPase [D12.776.543.585.813.625]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.543.585.813.750]

Sodium-Potassium-Exchanging ATPase Preferred

Concept UI: M0000394
Scope Note: An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
Terms: Sodium-Potassium-Exchanging ATPase Preferred Term
Term UI T694428
Date03/27/2007
LexicalTag ABX
ThesaurusID NLM (2008); Adenosinetriphosphatase, Sodium, Potassium
Term UI T000771
Date04/02/1992
LexicalTag NON
ThesaurusID NLM (1993); Sodium, Potassium Adenosinetriphosphatase
Term UI T000772
Date06/03/1988
LexicalTag NON
ThesaurusID UNK (19XX); ATPase, Sodium, Potassium
Term UI T000773
Date03/10/1978
LexicalTag NON
ThesaurusID UNK (19XX); Sodium, Potassium ATPase
Term UI T000774
Date03/10/1978
LexicalTag NON
ThesaurusID UNK (19XX); Potassium Pump
Term UI T000775
Date02/11/1993
LexicalTag NON
ThesaurusID NLM (1994); Sodium Pump
Term UI T000776
Date02/11/1993
LexicalTag NON
ThesaurusID NLM (1994); Sodium-Potassium Pump
Term UI T000777
Date02/11/1993
LexicalTag NON
ThesaurusID NLM (1994); Na(+) K(+)-Transporting ATPase
Term UI T000778
Date07/02/1993
LexicalTag NON
ThesaurusID NLM (1994); Na(+)-K(+)-Transporting ATPase
Term UI T000779
Date11/20/1992
LexicalTag NON
ThesaurusID NLM (1994); Na(+)-K(+)-Exchanging ATPase
Term UI T000780
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1979); Adenosine Triphosphatase, Sodium, Potassium
Term UI T000781
Date04/14/1992
LexicalTag NON
ThesaurusID NLM (1993); Sodium, Potassium Adenosine Triphosphatase
Term UI T000782
Date04/14/1992
LexicalTag NON
ThesaurusID NLM (1993)

Sodium-Potassium-Exchanging ATPase MeSH Descriptor Data 2025