MeSH Browser

MeSH Heading: Natural Resistance-associated Macrophage Protein 1
Tree Number(s): D12.776.157.530.450.162.236; D12.776.157.530.450.250.754; D12.776.543.550.190.359; D12.776.543.585.450.162.230; D12.776.543.585.450.250.695
Unique ID: D000099173
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099173
Scope Note: A cation transport protein that shares structural homology with prokaryotic and eukaryotic transport proteins. In mammals, it is a MACROPHAGE-specific antiporter, transporting metal ions in either direction against a proton gradient, and localizes to membranes of late ENDOSOMES and LYSOSOMES, where it may contribute to antimicrobial activity.
Entry Term(s): Natural Resistance-associated Macrophage Protein; Nramp Protein; Nramp1 Protein; SLC11A1 Protein; Solute Carrier 11a1; Solute Carrier Family 11-(proton-coupled divalent metal ion transporters), Member 1
Registry Numbers: 0
Public MeSH Note: 2026; NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1 was indexed under CATION TRANSPORT PROTEINS 2002-2025, and under CARRIER PROTEINS and MEMBRANE PROTEINS 1993-2001
History Note: 2026 (1993)
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Antiporters [D12.776.157.530.450.162]
        
        Chloride-Bicarbonate Antiporters [D12.776.157.530.450.162.193]
        
        Natural Resistance-associated Macrophage Protein 1 [D12.776.157.530.450.162.236]
        
        Potassium-Hydrogen Antiporters [D12.776.157.530.450.162.276]
        
        Reduced Folate Carrier Protein [D12.776.157.530.450.162.359]
        
        Sodium-Calcium Exchanger [D12.776.157.530.450.162.442]
        
        Sodium-Hydrogen Exchangers [D12.776.157.530.450.162.775]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.157.530.450.162.780]
        
        Vesicular Neurotransmitter Transport Proteins [D12.776.157.530.450.162.887]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Cation Transport Proteins [D12.776.157.530.450.250]
        
        Arsenite Transporting ATPases [D12.776.157.530.450.250.249]
        
        Calcium-Transporting ATPases [D12.776.157.530.450.250.500]
        
        Copper Transport Proteins [D12.776.157.530.450.250.578]
        
        Ferroportin [D12.776.157.530.450.250.695]
        
        Natural Resistance-associated Macrophage Protein 1 [D12.776.157.530.450.250.754]
        
        Organic Cation Transport Proteins [D12.776.157.530.450.250.812]
        
        Proton Pumps [D12.776.157.530.450.250.875]
        
        Sodium Sulfate Cotransporter [D12.776.157.530.450.250.878]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.157.530.450.250.880]
        
        Solute Carrier Family 11, Member 2 [D12.776.157.530.450.250.895]
        
        Solute Carrier Family 12 [D12.776.157.530.450.250.910]
        
        Zinc Transporter 8 [D12.776.157.530.450.250.940]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Antiporters [D12.776.543.550.190]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.550.190.276]
        
        Natural Resistance-associated Macrophage Protein 1 [D12.776.543.550.190.359]
        
        Potassium-Hydrogen Antiporters [D12.776.543.550.190.442]
        
        Reduced Folate Carrier Protein [D12.776.543.550.190.608]
        
        Sodium-Hydrogen Exchangers [D12.776.543.550.190.775]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Antiporters [D12.776.543.585.450.162]
        
        Chloride-Bicarbonate Antiporters [D12.776.543.585.450.162.193]
        
        Mitochondrial ADP, ATP Translocases [D12.776.543.585.450.162.225]
        
        Natural Resistance-associated Macrophage Protein 1 [D12.776.543.585.450.162.230]
        
        Organic Anion Transport Protein 1 [D12.776.543.585.450.162.234]
        
        Potassium-Hydrogen Antiporters [D12.776.543.585.450.162.276]
        
        Reduced Folate Carrier Protein [D12.776.543.585.450.162.359]
        
        Sodium-Calcium Exchanger [D12.776.543.585.450.162.442]
        
        Sodium-Hydrogen Exchangers [D12.776.543.585.450.162.775]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.543.585.450.162.800]
        
        Vesicular Neurotransmitter Transport Proteins [D12.776.543.585.450.162.887]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Cation Transport Proteins [D12.776.543.585.450.250]
        
        Arsenite Transporting ATPases [D12.776.543.585.450.250.249]
        
        Calcium-Transporting ATPases [D12.776.543.585.450.250.500]
        
        Copper Transport Proteins [D12.776.543.585.450.250.578]
        
        Natural Resistance-associated Macrophage Protein 1 [D12.776.543.585.450.250.695]
        
        Organic Cation Transport Proteins [D12.776.543.585.450.250.812]
        
        Proton Pumps [D12.776.543.585.450.250.875]
        
        Sodium Sulfate Cotransporter [D12.776.543.585.450.250.883]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.543.585.450.250.890]
        
        Solute Carrier Family 11, Member 2 [D12.776.543.585.450.250.904]
        
        Solute Carrier Family 12 [D12.776.543.585.450.250.918]
        
        Zinc Transporter 8 [D12.776.543.585.450.250.945]

Natural Resistance-associated Macrophage Protein 1 Preferred

Concept UI: M000768852
Registry Numbers: 0
Scope Note: A cation transport protein that shares structural homology with prokaryotic and eukaryotic transport proteins. In mammals, it is a MACROPHAGE-specific antiporter, transporting metal ions in either direction against a proton gradient, and localizes to membranes of late ENDOSOMES and LYSOSOMES, where it may contribute to antimicrobial activity.
Terms: Natural Resistance-associated Macrophage Protein 1 Preferred Term
Term UI T001147570
Date03/21/2025
LexicalTag NON
ThesaurusID NLM (2001); Natural Resistance-associated Macrophage Protein
Term UI T001147571
Date03/21/2025
LexicalTag NON
ThesaurusID NLM (1993); Nramp Protein
Term UI T001147572
Date03/21/2025
LexicalTag ABX
ThesaurusID NLM (1993); Nramp1 Protein
Term UI T001147573
Date03/21/2025
LexicalTag ABX
ThesaurusID NLM (1993); SLC11A1 Protein
Term UI T001147574
Date03/21/2025
LexicalTag ABX
ThesaurusID NLM (2001); Solute Carrier 11a1
Term UI T001147575
Date03/21/2025
LexicalTag NON
ThesaurusID NLM (2002); Solute Carrier Family 11-(proton-coupled divalent metal ion transporters), Member 1
Term UI T001147576
Date03/21/2025
LexicalTag NON
ThesaurusID NLM (2001)

Natural Resistance-associated Macrophage Protein 1 MeSH Descriptor Data 2026