MeSH Browser

MeSH Heading: Sodium-Potassium-Chloride Symporters
Tree Number(s): D12.776.157.530.450.625.875.750; D12.776.157.530.937.750; D12.776.543.585.450.625.750; D12.776.543.585.937.875
Unique ID: D028021
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D028021
Scope Note: A subclass of symporters that specifically transport SODIUM; POTASSIUM and CHLORIDE ions across cellular membranes in a tightly coupled electroneutrality process.
Entry Term(s): NKCC Proteins; NKCCs; Na(+), K(+), Cl(-)-Cotransporter; Na-K-Cl-Symporter; Na-K-Cl-Transporter; NaCl-KCl Cotransporter; NaK2Cl Symporter; Sodium, Potassium, Chloride-Cotransporter; Sodium-Potassium-Chloride Cotransporter; Sodium-Potassium-Chloride Cotransporters
Previous Indexing: Carrier Proteins (1984-2001)
Public MeSH Note: 2002; SODIUM, POTASSIUM, CHLORIDE-COTRANSPORTER was indexed under CARRIER PROTEINS 1984-2001
History Note: 2002; use SODIUM-POTASSIUM-CHLORIDE COTRANSPORTERS 1984-2001
Entry Combination: antagonists & inhibitors:Sodium Potassium Chloride Symporter Inhibitors
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2023/04/05

Entry Combination: antagonists & inhibitors:Sodium Potassium Chloride Symporter Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Symporters [D12.776.157.530.450.625]
        
        Solute Carrier Family 12 [D12.776.157.530.450.625.875]
        
        K Cl- Cotransporters [D12.776.157.530.450.625.875.500]
        
        Sodium-Potassium-Chloride Symporters [D12.776.157.530.450.625.875.750]
        
        Solute Carrier Family 12, Member 1 [D12.776.157.530.450.625.875.750.500]
        
        Solute Carrier Family 12, Member 2 [D12.776.157.530.450.625.875.750.625]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Solute Carrier Proteins [D12.776.157.530.937]
        
        Amino Acid Transport System X-AG [D12.776.157.530.937.250]
        
        Amino Acid Transport System y+L [D12.776.157.530.937.313]
        
        Amino Acid Transport System y+ [D12.776.157.530.937.375]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.157.530.937.500]
        
        Equilibrative Nucleoside Transport Proteins [D12.776.157.530.937.532]
        
        Glucose Transport Proteins, Facilitative [D12.776.157.530.937.563]
        
        K Cl- Cotransporters [D12.776.157.530.937.572]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.157.530.937.580]
        
        Mitochondrial ADP, ATP Translocases [D12.776.157.530.937.594]
        
        Mitochondrial Uncoupling Proteins [D12.776.157.530.937.598]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.157.530.937.600]
        
        Organic Anion Transport Protein 1 [D12.776.157.530.937.610]
        
        Organic Cation Transport Proteins [D12.776.157.530.937.612]
        
        Peptide Transporter 1 [D12.776.157.530.937.613]
        
        Proton-Coupled Folate Transporter [D12.776.157.530.937.618]
        
        Reduced Folate Carrier Protein [D12.776.157.530.937.622]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.157.530.937.624]
        
        SLC31 Proteins [D12.776.157.530.937.640]
        
        SLC4A Proteins [D12.776.157.530.937.656]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.157.530.937.688]
        
        Sodium-Glucose Transporter 1 [D12.776.157.530.937.696]
        
        Sodium-Glucose Transporter 2 [D12.776.157.530.937.700]
        
        Sodium-Hydrogen Exchangers [D12.776.157.530.937.703]
        
        Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.157.530.937.704]
        
        Sodium-Phosphate Cotransporter Proteins, Type III [D12.776.157.530.937.719]
        
        Sodium-Potassium-Chloride Symporters [D12.776.157.530.937.750]
        
        Solute Carrier Family 12, Member 1 [D12.776.157.530.937.750.500]
        
        Solute Carrier Family 12, Member 2 [D12.776.157.530.937.750.625]
        
        Solute Carrier Family 12, Member 3 [D12.776.157.530.937.750.750]
        
        Solute Carrier Family 44, Member 2 Protein [D12.776.157.530.937.828]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.157.530.937.905]
        
        Sulfate Transporters [D12.776.157.530.937.929]
        
        Urea Transporters [D12.776.157.530.937.941]
        
        Zinc Transporter 8 [D12.776.157.530.937.952]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Symporters [D12.776.543.585.450.625]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.543.585.450.625.124]
        
        GABA Plasma Membrane Transport Proteins [D12.776.543.585.450.625.139]
        
        Glutamate Plasma Membrane Transport Proteins [D12.776.543.585.450.625.147]
        
        Glycine Plasma Membrane Transport Proteins [D12.776.543.585.450.625.155]
        
        K Cl- Cotransporters [D12.776.543.585.450.625.171]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.543.585.450.625.186]
        
        Peptide Transporter 1 [D12.776.543.585.450.625.202]
        
        Proton-Coupled Folate Transporter [D12.776.543.585.450.625.217]
        
        Proton-Phosphate Symporters [D12.776.543.585.450.625.249]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.543.585.450.625.374]
        
        Sodium Sulfate Cotransporter [D12.776.543.585.450.625.437]
        
        Sodium-Bicarbonate Symporters [D12.776.543.585.450.625.500]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.543.585.450.625.531]
        
        Sodium-Glucose Transport Proteins [D12.776.543.585.450.625.562]
        
        Sodium-Phosphate Cotransporter Proteins [D12.776.543.585.450.625.625]
        
        Sodium-Potassium-Chloride Symporters [D12.776.543.585.450.625.750]
        
        Solute Carrier Family 12, Member 1 [D12.776.543.585.450.625.750.500]
        
        Solute Carrier Family 12, Member 2 [D12.776.543.585.450.625.750.625]
        
        Solute Carrier Family 12, Member 4 [D12.776.543.585.450.625.750.875]
        
        Solute Carrier Family 12 [D12.776.543.585.450.625.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Solute Carrier Proteins [D12.776.543.585.937]
        
        Amino Acid Transport System X-AG [D12.776.543.585.937.250]
        
        Amino Acid Transport System y+L [D12.776.543.585.937.313]
        
        Amino Acid Transport System y+ [D12.776.543.585.937.375]
        
        Dopamine Plasma Membrane Transport Proteins [D12.776.543.585.937.500]
        
        Equilibrative Nucleoside Transport Proteins [D12.776.543.585.937.563]
        
        Glucose Transport Proteins, Facilitative [D12.776.543.585.937.625]
        
        K Cl- Cotransporters [D12.776.543.585.937.657]
        
        Mitochondrial ADP, ATP Translocases [D12.776.543.585.937.688]
        
        Mitochondrial Uncoupling Proteins [D12.776.543.585.937.696]
        
        Norepinephrine Plasma Membrane Transport Proteins [D12.776.543.585.937.700]
        
        Organic Cation Transport Proteins [D12.776.543.585.937.701]
        
        Peptide Transporter 1 [D12.776.543.585.937.702]
        
        Organic Anion Transport Protein 1 [D12.776.543.585.937.719]
        
        Proton-Coupled Folate Transporter [D12.776.543.585.937.735]
        
        Reduced Folate Carrier Protein [D12.776.543.585.937.743]
        
        Serotonin Plasma Membrane Transport Proteins [D12.776.543.585.937.747]
        
        SLC31 Proteins [D12.776.543.585.937.762]
        
        SLC4A Proteins [D12.776.543.585.937.776]
        
        Sodium-Coupled Vitamin C Transporters [D12.776.543.585.937.813]
        
        Sodium-Glucose Transporter 1 [D12.776.543.585.937.821]
        
        Sodium-Glucose Transporter 2 [D12.776.543.585.937.825]
        
        Sodium-Hydrogen Exchangers [D12.776.543.585.937.828]
        
        Sodium-Phosphate Cotransporter Proteins, Type II [D12.776.543.585.937.829]
        
        Sodium-Phosphate Cotransporter Proteins, Type III [D12.776.543.585.937.844]
        
        Sodium-Potassium-Chloride Symporters [D12.776.543.585.937.875]
        
        Solute Carrier Family 12, Member 1 [D12.776.543.585.937.875.500]
        
        Solute Carrier Family 12, Member 2 [D12.776.543.585.937.875.625]
        
        Solute Carrier Family 12, Member 3 [D12.776.543.585.937.875.750]
        
        Solute Carrier Family 12, Member 4 [D12.776.543.585.937.875.875]
        
        Liver-Specific Organic Anion Transporter 1 [D12.776.543.585.937.901]
        
        Solute Carrier Family 44, Member 2 Protein [D12.776.543.585.937.926]
        
        Solute Carrier Organic Anion Transporter Family Member 1B3 [D12.776.543.585.937.950]
        
        Sulfate Transporters [D12.776.543.585.937.963]
        
        Urea Transporters [D12.776.543.585.937.969]
        
        Zinc Transporter 8 [D12.776.543.585.937.975]

Sodium-Potassium-Chloride Symporters Preferred

Concept UI: M0125395
Scope Note: A subclass of symporters that specifically transport SODIUM; POTASSIUM and CHLORIDE ions across cellular membranes in a tightly coupled electroneutrality process.
Terms: Sodium-Potassium-Chloride Symporters Preferred Term
Term UI T439799
Date03/19/2001
LexicalTag NON
ThesaurusID NLM (2002); NKCC Proteins
Term UI T001132989
Date02/16/2023
LexicalTag NON
ThesaurusID NLM (2024); NKCCs
Term UI T001132990
Date02/16/2023
LexicalTag ABB
ThesaurusID NLM (2024); Na(+), K(+), Cl(-)-Cotransporter
Term UI T155392
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); Na-K-Cl-Symporter
Term UI T155393
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); Na-K-Cl-Transporter
Term UI T155394
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); NaCl-KCl Cotransporter
Term UI T155396
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); NaK2Cl Symporter
Term UI T155397
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2002); Sodium-Potassium-Chloride Cotransporter
Term UI T155399
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Sodium, Potassium, Chloride-Cotransporter
Term UI T155400
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2002); Sodium-Potassium-Chloride Cotransporters
Term UI T439798
Date03/19/2001
LexicalTag NON
ThesaurusID NLM (2002)

Sodium-Potassium-Chloride Symporters MeSH Descriptor Data 2025