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Methotrexate MeSH Descriptor Data 2021


MeSH Heading
Methotrexate
Tree Number(s)
D03.633.100.733.631.192.500
Unique ID
D008727
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D008727
Scope Note
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Entry Term(s)
Amethopterin
Methotrexate Hydrate
Methotrexate Sodium
Methotrexate, (D)-Isomer
Methotrexate, (DL)-Isomer
Methotrexate, Dicesium Salt
Methotrexate, Disodium Salt
Methotrexate, Sodium Salt
Mexate
Pharm Action
Abortifacient Agents, Nonsteroidal
Antimetabolites, Antineoplastic
Dermatologic Agents
Enzyme Inhibitors
Folic Acid Antagonists
Immunosuppressive Agents
Antirheumatic Agents
Nucleic Acid Synthesis Inhibitors
Registry Number
YL5FZ2Y5U1
Related Numbers
133073-73-1
15475-56-6
3IG1E710ZN
51865-79-3
59-05-2
60388-53-6
86669-44-5
CAS Type 1 Name
L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-
NLM Classification #
QV 269
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2016/05/31
Methotrexate Preferred
Methotrexate, (D)-Isomer Narrower
Methotrexate, (DL)-Isomer Narrower
Mexate Narrower
Methotrexate Sodium Narrower
Methotrexate Hydrate Narrower
Methotrexate, Dicesium Salt Narrower
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