MeSH Browser

MeSH Heading: Islets of Langerhans
Tree Number(s): A03.734.414; A06.300.414
Unique ID: D007515
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007515
Annotation: do not confuse with LANGERHANS CELLS (skin); neoplasms = ADENOMA, ISLET CELL or CARCINOMA, ISLET CELL or their specifics
Scope Note: Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Entry Term(s): Islands of Langerhans; Islet Cells; Nesidioblasts; Pancreas, Endocrine; Pancreatic Islets
Public MeSH Note: 91; was ISLANDS OF LANGERHANS 1963-90
Online Note: use ISLETS OF LANGERHANS to search ISLANDS OF LANGERHANS 1966-90
History Note: 91; was ISLANDS OF LANGERHANS 1963-90
Entry Combination: transplantation:Islets of Langerhans Transplantation
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/07/01

Entry Combination: transplantation:Islets of Langerhans Transplantation
Allowable Qualifiers: abnormalities (AB)

anatomy & histology (AH)

blood supply (BS)

chemistry (CH)

cytology (CY)

diagnostic imaging (DG)

drug effects (DE)

embryology (EM)

enzymology (EN)

growth & development (GD)

immunology (IM)

injuries (IN)

innervation (IR)

metabolism (ME)

microbiology (MI)

parasitology (PS)

pathology (PA)

physiology (PH)

physiopathology (PP)

radiation effects (RE)

surgery (SU)

ultrastructure (UL)

virology (VI)

Concept UI: M0011741
Scope Note: Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Terms: Islets of Langerhans Preferred Term
Term UI T022595
Date01/01/1999
LexicalTag EPO
ThesaurusID NLM (1966); Nesidioblasts
Term UI T022596
Date04/26/1982
LexicalTag NON
ThesaurusID UNK (19XX); Pancreas, Endocrine
Term UI T022597
Date05/25/1979
LexicalTag NON
ThesaurusID UNK (19XX); Islet Cells
Term UI T022598
Date07/25/1996
LexicalTag NON
ThesaurusID NLM (1998); Pancreatic Islets
Term UI T458454
Date08/22/2001
LexicalTag NON
ThesaurusID NLM (2003); Islands of Langerhans
Term UI T022594
Date04/26/1990
LexicalTag EPO
ThesaurusID NLM (1991)

Islets of Langerhans MeSH Descriptor Data 2025