MeSH Browser

MeSH Heading: Somatostatin
Tree Number(s): D06.472.699.327.700.875; D06.472.699.587.780; D12.644.400.400.700.875; D12.644.548.365.700.875; D12.644.548.586.780; D12.776.631.650.405.700.875
Unique ID: D013004
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013004
Scope Note: A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
Entry Term(s): Cyclic Somatostatin; SRIH-14; Somatofalk; Somatostatin, Cyclic; Somatostatin-14; Somatotropin Release-Inhibiting Factor; Somatotropin Release-Inhibiting Hormone; Stilamin
Pharm Action: Hormones
Registry Number: 51110-01-1
NLM Classification #: WK 515
Previous Indexing: Somatotropin Releasing Hormone/antagonists & inhibitors (1974); Somatotropin/antagonists & inhibitors (1973-1974)
See Also: Receptors, Somatostatin
Public MeSH Note: 99
Online Note: use SOMATOSTATIN to search SOMATOTROPIN RELEASE INHIBITING HORMONE 1975-84
History Note: 99
Date Established: 1975/09/01
Date of Entry: 1974/11/11
Revision Date: 2015/11/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Hypothalamic Hormones [D06.472.699.327]
      - Pituitary Hormone Release Inhibiting Hormones [D06.472.699.327.700]
        
        MSH Release-Inhibiting Hormone [D06.472.699.327.700.500]
        
        Prolactin Release-Inhibiting Factors [D06.472.699.327.700.750]
        
        Somatostatin [D06.472.699.327.700.875]
        
        Somatostatin-28 [D06.472.699.327.700.875.500]

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Pancreatic Hormones [D06.472.699.587]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Neuropeptides [D12.644.400]
    - Hypothalamic Hormones [D12.644.400.400]
      - Pituitary Hormone Release Inhibiting Hormones [D12.644.400.400.700]
        
        MSH Release-Inhibiting Hormone [D12.644.400.400.700.500]
        
        Prolactin Release-Inhibiting Factors [D12.644.400.400.700.750]
        
        Somatostatin [D12.644.400.400.700.875]
        
        Somatostatin-28 [D12.644.400.400.700.875.500]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Hypothalamic Hormones [D12.644.548.365]
      - Pituitary Hormone Release Inhibiting Hormones [D12.644.548.365.700]
        
        MSH Release-Inhibiting Hormone [D12.644.548.365.700.500]
        
        Prolactin Release-Inhibiting Factors [D12.644.548.365.700.750]
        
        Somatostatin [D12.644.548.365.700.875]
        
        Somatostatin-28 [D12.644.548.365.700.875.500]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Pancreatic Hormones [D12.644.548.586]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nerve Tissue Proteins [D12.776.631]
    - Neuropeptides [D12.776.631.650]
      - Hypothalamic Hormones [D12.776.631.650.405]
        
        Pituitary Hormone Release Inhibiting Hormones [D12.776.631.650.405.700]
        
        MSH Release-Inhibiting Hormone [D12.776.631.650.405.700.500]
        
        Prolactin Release-Inhibiting Factors [D12.776.631.650.405.700.750]
        
        Somatostatin [D12.776.631.650.405.700.875]
        
        Somatostatin-28 [D12.776.631.650.405.700.875.500]

Somatostatin Preferred

Concept UI: M0020152
Registry Number: 51110-01-1
Scope Note: A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
Terms: Somatostatin Preferred Term
Term UI T038312
Date01/01/1999
LexicalTag NON
ThesaurusID; SRIH-14
Term UI T038314
Date01/03/1985
LexicalTag ACR
ThesaurusID UNK (19XX); Somatotropin Release-Inhibiting Factor
Term UI T665673
Date02/02/2006
LexicalTag NON
ThesaurusID NLM (2007); Cyclic Somatostatin
Term UI T038316
Date05/13/1994
LexicalTag NON
ThesaurusID NLM (1995); Somatostatin-14
Term UI T038317
Date06/08/1984
LexicalTag NON
ThesaurusID UNK (19XX); Somatotropin Release-Inhibiting Hormone
Term UI T038313
Date06/08/1984
LexicalTag NON
ThesaurusID UNK (19XX); Somatostatin, Cyclic
Term UI T038315
Date04/04/1994
LexicalTag NON
ThesaurusID NLM (1995)

Stilamin Narrower

Somatofalk Narrower

Somatostatin MeSH Descriptor Data 2023