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The common precursor polypeptide of pancreatic GLUCAGON and intestinal GLUCAGON-LIKE PEPTIDES. Proglucagon is the 158-amino acid segment of preproglucagon without the N-terminal signal sequence. Proglucagon is expressed in the PANCREAS; INTESTINES; and the CENTRAL NERVOUS SYSTEM. Posttranslational processing of proglucagon is tissue-specific yielding numerous bioactive peptides.
Entry Term(s)
Glucagon Precursor
Glucagon Precursors
Pre-Proglucagons
Preproglucagon
Preproglucagons
Pro-Glucagon
Registry Numbers
55963-74-1
0
Previous Indexing
Enteroglucagon (1982-2005)
Glucagon (1973-2005)
Public MeSH Note
2007; see GLUCAGON PRECURSORS 2006; GLUCAGON PRECURSOR was indexed under PROGLUCAGON 2006-2007, PROTEIN PRECURSORS & GLUCAGON 1977-2005
History Note
2007 (2006); for GLUCAGON PRECURSOR use GLUCAGON PRECURSOR (NM) 1977-2007
The common precursor polypeptide of pancreatic GLUCAGON and intestinal GLUCAGON-LIKE PEPTIDES. Proglucagon is the 158-amino acid segment of preproglucagon without the N-terminal signal sequence. Proglucagon is expressed in the PANCREAS; INTESTINES; and the CENTRAL NERVOUS SYSTEM. Posttranslational processing of proglucagon is tissue-specific yielding numerous bioactive peptides.