MeSH Browser

MeSH Heading: Epidermal Growth Factor
Tree Number(s): D06.472.317.350; D12.644.276.382.500; D12.776.467.382.500; D23.529.382.500
Unique ID: D004815
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004815
Scope Note: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
Entry Term(s): EGF; Epidermal Growth Factor-Urogastrone; Human Urinary Gastric Inhibitor; Urogastrone; beta-Urogastrone
CAS Type 1 Name: Epidermal growth factor
NLM Classification #: WK 170
Previous Indexing: Gastrointestinal Hormones (1966-1974); Growth Substances (1966-1976); Peptides (1966-1976)
See Also: Anti-Ulcer Agents; ErbB Receptors; Gastrointestinal Agents
Public MeSH Note: 2000; see EPIDERMAL GROWTH FACTOR-UROGASTRONE 1982-1999, see PEPTIDES 1977-1981; for UROGASTRONE see GASTROINTESTINAL HORMONES 1963-1981
History Note: 2000(1982); use PEPTIDES 1977-1981; for UROGASTRONE use GASTROINTESTINAL HORMONES 1963-1981
Date Established: 1982/01/01
Date of Entry: 1976/04/16
Revision Date: 2018/07/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0007549
Scope Note: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
Terms: Epidermal Growth Factor Preferred Term
Term UI T014683
Date05/11/1987
LexicalTag NON
ThesaurusID UNK (19XX); beta-Urogastrone
Term UI T014682
Date11/29/1982
LexicalTag NON
ThesaurusID UNK (19XX); EGF
Term UI T014685
Date09/01/1994
LexicalTag ABB
ThesaurusID NLM (1996); Epidermal Growth Factor-Urogastrone
Term UI T014684
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); Human Urinary Gastric Inhibitor
Term UI T014686
Date12/06/1988
LexicalTag NON
ThesaurusID NLM (1990); Urogastrone
Term UI T014687
Date05/12/1981
LexicalTag NON
ThesaurusID UNK (19XX)

Epidermal Growth Factor MeSH Descriptor Data 2025