MeSH Browser

MeSH Heading: Heparin-binding EGF-like Growth Factor
Tree Number(s): D12.644.276.382.625; D12.776.467.382.625; D23.529.382.625
Unique ID: D066257
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D066257
Scope Note: An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.
Entry Term(s): Diphtheria Toxin Receptor; Diphtheria Toxin Receptors; HB-EGF; HB-EGF Precursor; Heparin-binding EGF-like Growth-Factor; Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein; Receptor, Diphtheria Toxin; SF HB-EGF; Short Form HB-EGF
Public MeSH Note: 2015; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR was indexed under INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2008-2014, and under EPIDERMAL GROWTH FACTOR 1992-2007
History Note: 2015
Date Established: 2015/01/01
Date of Entry: 2014/06/26
Revision Date: 2014/06/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0593431
Scope Note: An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.
Terms: Heparin-binding EGF-like Growth Factor Preferred Term
Term UI T859501
Date05/09/2014
LexicalTag NON
ThesaurusID NLM (2015); Heparin-binding EGF-like Growth-Factor
Term UI T858324
Date04/11/2014
LexicalTag ABX
ThesaurusID NLM (2015); HB-EGF
Term UI T229618
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (1992)

Heparin-binding EGF-like Growth Factor MeSH Descriptor Data 2025