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Diphtheria Toxin MeSH Descriptor Data 2022


MeSH Heading
Diphtheria Toxin
Tree Number(s)
D08.811.913.400.725.115.220
D23.946.123.305
Unique ID
D004167
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D004167
Annotation
/antag permitted but consider also DIPHTHERIA ANTITOXIN
Scope Note
An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
Entry Term(s)
Corynebacterium Diphtheriae Toxin
Toxin, Corynebacterium Diphtheriae
Pharm Action
Poisons
Registry Number
0
NLM Classification #
WC 320
See Also
Diphtheria Toxoid
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2007/07/09
Diphtheria Toxin Preferred
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