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Tetanus Toxin MeSH Descriptor Data 2022


MeSH Heading
Tetanus Toxin
Tree Number(s)
D12.776.097.872
D23.946.123.893
Unique ID
D013744
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D013744
Annotation
/antag permitted but consider also TETANUS ANTITOXIN
Scope Note
Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
Entry Term(s)
Clostridial Neurotoxin
Clostridium tetani Toxin
Tetanus Toxins
Pharm Action
Neurotoxins
Registry Number
0
NLM Classification #
WC 320
See Also
Tetanus Antitoxin
Public MeSH Note
65
History Note
65
Date Established
1965/01/01
Date of Entry
1999/01/01
Revision Date
2020/05/27
Tetanus Toxin Preferred
Clostridial Neurotoxin Narrower
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