MeSH Browser

MeSH Heading: Tetanus Toxin
Tree Number(s): D12.776.097.872; D23.946.123.893
Unique ID: D013744
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013744
Annotation: /antag permitted but consider also TETANUS ANTITOXIN
Scope Note: Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
Entry Term(s): Clostridial Neurotoxin; Clostridium tetani Toxin; Tetanus Toxins
Pharm Action: Neurotoxins
NLM Classification #: WC 320
See Also: Tetanus Antitoxin
Public MeSH Note: 65
History Note: 65
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0021202
Scope Note: Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
Terms: Tetanus Toxin Preferred Term
Term UI T040367
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1965); Clostridium tetani Toxin
Term UI T040365
Date06/17/1985
LexicalTag NON
ThesaurusID UNK (19XX); Tetanus Toxins
Term UI T040366
Date10/12/1999
LexicalTag NON
ThesaurusID UNK (19XX)

Tetanus Toxin MeSH Descriptor Data 2025